TY - JOUR
T1 - Arthritis, Sleep Health, and Systemic Inflammation in Older Men
AU - Lee, Soomi
AU - Stone, Katie L.
AU - Engeland, Christopher G.
AU - Lane, Nancy E.
AU - Buxton, Orfeu M.
N1 - Publisher Copyright:
© 2019, American College of Rheumatology
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objective: To examine the associations of prevalent arthritis with systemic inflammation in older men and to test whether sleep health mediates the associations. Methods: Cross-sectional data came from 2,562 community-dwelling older men (all were age 65 years or older; mean age 76 years) in the Osteoporotic Fractures in Men Study who participated in a sleep ancillary study in 2003–2005. Participants were classified as having osteoarthritis (OA) (24%) or rheumatoid arthritis (RA) (0.7%) based on self-reported diagnoses and medication use. We constructed a composite score of multidimensional sleep health (i.e., perceived sleep quality, sleepiness, frequency of daytime napping, wake after sleep onset, and sleep duration) measured by both self-report and actigraphy. We also created binary indicators of elevated inflammation using C-reactive protein (CRP) (>3 mg/liter) and interleukin-6 (IL-6) (>1.08 pg/ml) levels. Analyses controlled for age, diagnosed sleep disorders, body mass index, smoking status, relevant medication use, and comorbidities. Results: Older men with OA did not have higher risk of elevated CRP or IL-6 levels. However, indirect associations of OA through sleep health were found. OA was associated with poorer sleep health, which was further associated with 16% higher odds of elevated CRP (P < 0.001) and 12% higher odds of elevated IL-6 (P < 0.01) levels after controlling for OA. Older men with RA had higher odds of elevated CRP and IL-6 levels, but the associations were not mediated by sleep health. Conclusion: Findings suggest that promoting sleep health may help reduce the risk of systemic inflammation in older men with OA.
AB - Objective: To examine the associations of prevalent arthritis with systemic inflammation in older men and to test whether sleep health mediates the associations. Methods: Cross-sectional data came from 2,562 community-dwelling older men (all were age 65 years or older; mean age 76 years) in the Osteoporotic Fractures in Men Study who participated in a sleep ancillary study in 2003–2005. Participants were classified as having osteoarthritis (OA) (24%) or rheumatoid arthritis (RA) (0.7%) based on self-reported diagnoses and medication use. We constructed a composite score of multidimensional sleep health (i.e., perceived sleep quality, sleepiness, frequency of daytime napping, wake after sleep onset, and sleep duration) measured by both self-report and actigraphy. We also created binary indicators of elevated inflammation using C-reactive protein (CRP) (>3 mg/liter) and interleukin-6 (IL-6) (>1.08 pg/ml) levels. Analyses controlled for age, diagnosed sleep disorders, body mass index, smoking status, relevant medication use, and comorbidities. Results: Older men with OA did not have higher risk of elevated CRP or IL-6 levels. However, indirect associations of OA through sleep health were found. OA was associated with poorer sleep health, which was further associated with 16% higher odds of elevated CRP (P < 0.001) and 12% higher odds of elevated IL-6 (P < 0.01) levels after controlling for OA. Older men with RA had higher odds of elevated CRP and IL-6 levels, but the associations were not mediated by sleep health. Conclusion: Findings suggest that promoting sleep health may help reduce the risk of systemic inflammation in older men with OA.
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U2 - 10.1002/acr.23923
DO - 10.1002/acr.23923
M3 - Article
C2 - 31074577
AN - SCOPUS:85085603945
SN - 2151-464X
VL - 72
SP - 965
EP - 973
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 7
ER -