TY - JOUR
T1 - Ascorbic acid and the behavioral response to haloperidol
T2 - Implications for the action of antipsychotic drugs
AU - Rebec, George V.
AU - Centore, Josephine M.
AU - White, Laura K.
AU - Alloway, Kevin D.
PY - 1985
Y1 - 1985
N2 - Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.
AB - Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.
UR - http://www.scopus.com/inward/record.url?scp=0021915009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021915009&partnerID=8YFLogxK
U2 - 10.1126/science.4038426
DO - 10.1126/science.4038426
M3 - Article
C2 - 4038426
AN - SCOPUS:0021915009
SN - 0036-8075
VL - 227
SP - 438
EP - 440
JO - Science
JF - Science
IS - 4685
ER -