TY - JOUR
T1 - Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing
AU - Zhao, Nan
AU - Coyne, James
AU - Xu, Ming
AU - Zhang, Xiaolong
AU - Suzuki, Akiho
AU - Shi, Peng
AU - Lai, Jinping
AU - Fong, Guo Hua
AU - Xiong, Na
AU - Wang, Yong
N1 - Publisher Copyright:
© Copyright 2019 American Chemical Society.
PY - 2019/2/12
Y1 - 2019/2/12
N2 - Macromolecular assembly has been studied for various applications. However, although macromolecules can recognize one another for assembly, their assembled structures usually lack the function of specific molecular recognition. We hypothesized that bifunctional aptamer-protein macromers would possess dual functions of molecular assembly and recognition. The data show that hybrid aptamer-fibrinogen macromers can assemble to form hydrogels. Moreover, the assembled hydrogels can recognize vascular endothelial growth factor (VEGF) for sustained release. When the VEGF-loaded hydrogels are implanted in vivo, they can promote angiogenesis and skin wound healing. Thus, this work has successfully demonstrated a promising macromolecular system for broad applications, such as drug delivery and regenerative medicine.
AB - Macromolecular assembly has been studied for various applications. However, although macromolecules can recognize one another for assembly, their assembled structures usually lack the function of specific molecular recognition. We hypothesized that bifunctional aptamer-protein macromers would possess dual functions of molecular assembly and recognition. The data show that hybrid aptamer-fibrinogen macromers can assemble to form hydrogels. Moreover, the assembled hydrogels can recognize vascular endothelial growth factor (VEGF) for sustained release. When the VEGF-loaded hydrogels are implanted in vivo, they can promote angiogenesis and skin wound healing. Thus, this work has successfully demonstrated a promising macromolecular system for broad applications, such as drug delivery and regenerative medicine.
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U2 - 10.1021/acs.chemmater.8b04486
DO - 10.1021/acs.chemmater.8b04486
M3 - Article
C2 - 31558852
AN - SCOPUS:85060796650
SN - 0897-4756
VL - 31
SP - 1006
EP - 1015
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 3
ER -