Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring

Zheng Li; Lovisa C. Romanoff; Debra A. Trinidad; Narisa Hussain; Richard S. Jones; Erin N. Porter; Larry L. Needham; Donald G. Patterson; Andreas Sjodin

Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring

Zheng Li
, Lovisa C. Romanoff
, Debra A. Trinidad
, Narisa Hussain
, Richard S. Jones
, Erin N. Porter
, Larry L. Needham
, Donald G. Patterson
, Andreas Sjodin

Forensic Science Program

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Polycyclic aromatic hydrocarbons (PAHs), a class of carcinogenic and mutagenic pollutants formed during incomplete combustion processes, are found in automobile exhausts, forest fires, cigarette smoke and certain foods such as charbroiled meat. Human exposure to environmental PAHs can be assessed by measuring levels of their urinary metabolites, hydroxy-PAHs (OH-PAHs). We have developed a method for the measurement of 24 OH-PAHs in urine. The method consists of enzymatic hydrolysis, automated liquid-liquid extraction, derivatization and quantification by gas chromatography/isotope dilution high-resolution mass spectrometry (GC/IDHRMS). The limits of detection were in the low parts-per-trillion range. The CVs were 2.9-11%, method recoveries were 46-72% and the throughput was 40 samples per day per analyst. This method has been applied to the analysis of samples from the National Health and Nutrition Examination Survey (NHANES), performed by CDC to assess exposure of the U.S. general population to environmental pollutants.

Original language	English (US)
Title of host publication	Abstracts of Papers - 232nd American Chemical Society Meeting and Exposition
State	Published - 2006
Event	232nd American Chemical Society Meeting and Exposition - San Francisco, CA, United States Duration: Sep 10 2006 → Sep 14 2006

Publication series

Name	ACS National Meeting Book of Abstracts
Volume	232
ISSN (Print)	0065-7727

Other

Other	232nd American Chemical Society Meeting and Exposition
Country/Territory	United States
City	San Francisco, CA
Period	9/10/06 → 9/14/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

Cite this

@inproceedings{ca3826bb60434758ac782e0e4e57004a,

title = "Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring",

abstract = "Polycyclic aromatic hydrocarbons (PAHs), a class of carcinogenic and mutagenic pollutants formed during incomplete combustion processes, are found in automobile exhausts, forest fires, cigarette smoke and certain foods such as charbroiled meat. Human exposure to environmental PAHs can be assessed by measuring levels of their urinary metabolites, hydroxy-PAHs (OH-PAHs). We have developed a method for the measurement of 24 OH-PAHs in urine. The method consists of enzymatic hydrolysis, automated liquid-liquid extraction, derivatization and quantification by gas chromatography/isotope dilution high-resolution mass spectrometry (GC/IDHRMS). The limits of detection were in the low parts-per-trillion range. The CVs were 2.9-11\%, method recoveries were 46-72\% and the throughput was 40 samples per day per analyst. This method has been applied to the analysis of samples from the National Health and Nutrition Examination Survey (NHANES), performed by CDC to assess exposure of the U.S. general population to environmental pollutants.",

author = "Zheng Li and Romanoff, \{Lovisa C.\} and Trinidad, \{Debra A.\} and Narisa Hussain and Jones, \{Richard S.\} and Porter, \{Erin N.\} and Needham, \{Larry L.\} and Patterson, \{Donald G.\} and Andreas Sjodin",

year = "2006",

language = "English (US)",

isbn = "0841274266",

series = "ACS National Meeting Book of Abstracts",

booktitle = "Abstracts of Papers - 232nd American Chemical Society Meeting and Exposition",

}

Li, Z, Romanoff, LC, Trinidad, DA, Hussain, N, Jones, RS, Porter, EN, Needham, LL, Patterson, DG & Sjodin, A 2006, Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring. in Abstracts of Papers - 232nd American Chemical Society Meeting and Exposition. ACS National Meeting Book of Abstracts, vol. 232, 232nd American Chemical Society Meeting and Exposition, San Francisco, CA, United States, 9/10/06.

Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring. / Li, Zheng; Romanoff, Lovisa C.; Trinidad, Debra A. et al.
Abstracts of Papers - 232nd American Chemical Society Meeting and Exposition. 2006. (ACS National Meeting Book of Abstracts; Vol. 232).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring

AU - Li, Zheng

AU - Romanoff, Lovisa C.

AU - Trinidad, Debra A.

AU - Hussain, Narisa

AU - Jones, Richard S.

AU - Porter, Erin N.

AU - Needham, Larry L.

AU - Patterson, Donald G.

AU - Sjodin, Andreas

PY - 2006

Y1 - 2006

N2 - Polycyclic aromatic hydrocarbons (PAHs), a class of carcinogenic and mutagenic pollutants formed during incomplete combustion processes, are found in automobile exhausts, forest fires, cigarette smoke and certain foods such as charbroiled meat. Human exposure to environmental PAHs can be assessed by measuring levels of their urinary metabolites, hydroxy-PAHs (OH-PAHs). We have developed a method for the measurement of 24 OH-PAHs in urine. The method consists of enzymatic hydrolysis, automated liquid-liquid extraction, derivatization and quantification by gas chromatography/isotope dilution high-resolution mass spectrometry (GC/IDHRMS). The limits of detection were in the low parts-per-trillion range. The CVs were 2.9-11%, method recoveries were 46-72% and the throughput was 40 samples per day per analyst. This method has been applied to the analysis of samples from the National Health and Nutrition Examination Survey (NHANES), performed by CDC to assess exposure of the U.S. general population to environmental pollutants.

AB - Polycyclic aromatic hydrocarbons (PAHs), a class of carcinogenic and mutagenic pollutants formed during incomplete combustion processes, are found in automobile exhausts, forest fires, cigarette smoke and certain foods such as charbroiled meat. Human exposure to environmental PAHs can be assessed by measuring levels of their urinary metabolites, hydroxy-PAHs (OH-PAHs). We have developed a method for the measurement of 24 OH-PAHs in urine. The method consists of enzymatic hydrolysis, automated liquid-liquid extraction, derivatization and quantification by gas chromatography/isotope dilution high-resolution mass spectrometry (GC/IDHRMS). The limits of detection were in the low parts-per-trillion range. The CVs were 2.9-11%, method recoveries were 46-72% and the throughput was 40 samples per day per analyst. This method has been applied to the analysis of samples from the National Health and Nutrition Examination Survey (NHANES), performed by CDC to assess exposure of the U.S. general population to environmental pollutants.

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UR - https://www.scopus.com/pages/publications/34047269625#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:34047269625

SN - 0841274266

SN - 9780841274266

T3 - ACS National Meeting Book of Abstracts

BT - Abstracts of Papers - 232nd American Chemical Society Meeting and Exposition

T2 - 232nd American Chemical Society Meeting and Exposition

Y2 - 10 September 2006 through 14 September 2006

ER -

Assessing human exposure to polycyclic aromatic hydrocarbons by urinary biomonitoring

Abstract

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UN SDGs

All Science Journal Classification (ASJC) codes

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