Assessing potential impact of 2015 American Thyroid Association guidelines on community standard practice for I-131 treatment of low-risk differentiated thyroid cancer: case study of Jordan

Objectives: The 2015 American Thyroid Association (ATA) guidelines called for significantly more selective ¹³¹I therapy in patients with low-risk differentiated thyroid cancer (DTC). We hypothesized that application of these guidelines would significantly reduce the ¹³¹I activity utilized by an academic tertiary hospital in Jordan. Methods: All DTC patients managed at Jordan University Hospital (JUH) between 1/2009 and 6/2019 were classified according to the 2015 ATA risk category and ¹³¹I activity was assigned accordingly. The actual ¹³¹I activity administered was compared with that recommended by the 2015 ATA guidelines. Results: In total, 135/182 DTC patients (74.2%) managed at JUH underwent ¹³¹I therapy. Of those, 58 (43%) had ATA low-, 58 (43%) intermediate-, and 19 (14%) high-risk disease. The low-, intermediate-, and high-risk DTC patients received an average (±SD) initial ¹³¹I activity of 3.53 ± 0.95, 4.40 ± 1.49, and 5.06 ± 2.52 GBq, respectively. Withholding ¹³¹I therapy altogether in the 2015 ATA low-risk patients would result in decreasing the ¹³¹I activity in the overall patient population by 37%. Withholding ¹³¹I therapy only in low-risk papillary thyroid microcarcinomas while administering 1.11 GBq of ¹³¹I to other low-risk patients would result in 28% reduction of ¹³¹I. Conclusion: This study demonstrates a significant reduction in ¹³¹I therapeutic activity that would be given to DTC patients in an academic tertiary setting in Jordan, following acceptance of the 2015 ATA recommendations. Institutions that adopted the 2015 ATA guidance should measure outcomes in comparison to their historical controls and report those findings, while long-term results of randomized controlled trials are forthcoming.