Assessing the aneurysm occlusion efficacy of a shear-thinning biomaterial in a 3D-printed model

Grant Schroeder, Masoud Edalati, Gregory Tom, Nicole Kuntjoro, Mark Gutin, Melvin Gurian, Edoardo Cuniberto, Elisabeth Hirth, Alessia Martiri, Maria Teresa Sposato, Selda Aminzadeh, James Eichenbaum, Parvin Alizadeh, Avijit Baidya, Reihaneh Haghniaz, Rohollah Nasiri, Naoki Kaneko, Abraham Mansouri, Ali Khademhosseini, Amir Sheikhi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Metallic coil embolization is a common method for the endovascular treatment of visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA); however, this treatment is suboptimal due to the high cost of coils, incomplete volume occlusion, poor reendothelialization, aneurysm puncture, and coil migration. Several alternative treatment strategies are available, including stent flow diverters, glue embolics, gelfoam slurries, and vascular mesh plugs—each of which have their own disadvantages. Here, we investigated the in vitro capability of a shear-thinning biomaterial (STB), a nanocomposite hydrogel composed of gelatin and silicate nanoplatelets, for the minimally-invasive occlusion of simple necked aneurysm models. We demonstrated the injectability of STB through various clinical catheters, engineered an in vitro testing apparatus to independently manipulate aneurysm neck diameter, fluid flow rate, and flow waveform, and tested the stability of STB within the models under various conditions. Our experiments show that STB is able to withstand at least 1.89 Pa of wall shear stress, as estimated by computational fluid dynamics. STB is also able to withstand up to 10 mL s−1 pulsatile flow with a waveform mimicking blood flow in the human femoral artery and tolerate greater pressure changes than those in the human aorta. We ultimately found that our in vitro system was limited by supraphysiologic pressure changes caused by aneurysm models with low compliance.

Original languageEnglish (US)
Article number105156
JournalJournal of the Mechanical Behavior of Biomedical Materials
StatePublished - Jun 2022

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials


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