Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?

Janie Allaire; Denis Talbot; Patrick Couture; André Tchernof; Peter J.H. Jones; Penny Kris-Etherton; Sheila G. West; Philip W. Connelly; David J.A. Jenkins; Benoît Lamarche

doi:10.1038/s41430-018-0257-0

Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?

Janie Allaire, Denis Talbot, Patrick Couture, André Tchernof, Peter J.H. Jones, Penny Kris-Etherton, Sheila G. West, Philip W. Connelly, David J.A. Jenkins, Benoît Lamarche

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.

Original language	English (US)
Pages (from-to)	1546-1550
Number of pages	5
Journal	European Journal of Clinical Nutrition
Volume	73
Issue number	11
DOIs	https://doi.org/10.1038/s41430-018-0257-0
State	Published - Nov 1 2019

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1038/s41430-018-0257-0

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Allaire, J., Talbot, D., Couture, P., Tchernof, A., Jones, P. J. H., Kris-Etherton, P., West, S. G., Connelly, P. W., Jenkins, D. J. A., & Lamarche, B. (2019). Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary? European Journal of Clinical Nutrition, 73(11), 1546-1550. https://doi.org/10.1038/s41430-018-0257-0

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abstract = "The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.",

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AU - Jones, Peter J.H.

AU - Kris-Etherton, Penny

AU - West, Sheila G.

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AU - Jenkins, David J.A.

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Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?

Abstract

All Science Journal Classification (ASJC) codes

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