TY - JOUR
T1 - Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias
AU - Naccarelli, Gerald
AU - Dougherty, Anne H.
AU - Berns, Ellison
AU - Rinkenberger, Robert L.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/8/29
Y1 - 1986/8/29
N2 - Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.
AB - Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.
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U2 - 10.1016/0002-9149(86)90101-3
DO - 10.1016/0002-9149(86)90101-3
M3 - Article
C2 - 3529906
AN - SCOPUS:0022507161
SN - 0002-9149
VL - 58
SP - C31-C36
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 5
ER -