TY - JOUR
T1 - Association between a Healthy Lifestyle Score and inflammatory markers among Puerto Rican adults
AU - Sotos-Prieto, M.
AU - Bhupathiraju, S. N.
AU - Falcon, L. M.
AU - Gao, X.
AU - Tucker, K. L.
AU - Mattei, J.
N1 - Funding Information:
Supported by NIH grants P01-AG023394, P50-HL105185, R01-AG027087 and K01-HL120951. M.S.P. was supported by a research fellowship from Fundación Alfonso Martín Escudero, Spain. J.M was supported by NIH-National Heart Lung and Blood Institute K01 Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (grant number K01-HL120951). All authors declare no conflict of interest.
Funding Information:
Supported by NIH grants P01-AG023394 , P50-HL105185 , R01-AG027087 and K01-HL120951 . M.S.P. was supported by a research fellowship from Fundación Alfonso Martín Escudero, Spain . J.M was supported by NIH-National Heart Lung and Blood Institute K01 Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (grant number K01-HL120951 ).
Publisher Copyright:
© 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background and aims: The relationship between multiple lifestyle components analyzed in combination and inflammation remains understudied. We aimed to assess the association between a Healthy Lifestyle Score (HLS) that includes adherence to five behavioral components (diet, physical activity and sedentary behaviors, smoking, social support and network, and sleep) and inflammatory markers, as well as the role of the HLS in inflammation among individuals with cardiometabolic conditions, in Puerto Rican adults. Methods and results: In a cross-sectional study of 842 Puerto Ricans adults (aged 45-75 y) living in Boston, MA, the HLS (range = 0-190; maximum indicative of healthiest adherence) was analyzed for association with three inflammatory markers: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). In multivariable-adjusted models, the HLS was inversely associated with IL-6 (β ± SE = -0.55 ± 0.13; P < 0.001) and TNF-α (-0.39 ± 0.13; P = 0.004). The dietary and smoking components were associated with both inflammatory markers independently of the other HLS components. Significant inverse associations were observed for each 20-unit increase in HLS and IL-6 and TNF-α for participants with hypertension (n = 600; β ± SE = -0.58 ± 0.16; -0.46 ± 0.16, respectively) and with overweight/obesity (n = 743; β ± SE = -0.59 ± 0.13; -0.50 ± 0.14, respectively), but not for those with diabetes (n = 187) or heart disease (n = 192). The HLS was not associated with CRP, after adjustment for potential confounders. Conclusion: Higher adherence to multiple lifestyle behaviors was associated with lower concentrations of inflammatory markers. Because low-grade inflammation may precede chronic diseases, following an overall healthy lifestyle may help lower risk of these diseases.
AB - Background and aims: The relationship between multiple lifestyle components analyzed in combination and inflammation remains understudied. We aimed to assess the association between a Healthy Lifestyle Score (HLS) that includes adherence to five behavioral components (diet, physical activity and sedentary behaviors, smoking, social support and network, and sleep) and inflammatory markers, as well as the role of the HLS in inflammation among individuals with cardiometabolic conditions, in Puerto Rican adults. Methods and results: In a cross-sectional study of 842 Puerto Ricans adults (aged 45-75 y) living in Boston, MA, the HLS (range = 0-190; maximum indicative of healthiest adherence) was analyzed for association with three inflammatory markers: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). In multivariable-adjusted models, the HLS was inversely associated with IL-6 (β ± SE = -0.55 ± 0.13; P < 0.001) and TNF-α (-0.39 ± 0.13; P = 0.004). The dietary and smoking components were associated with both inflammatory markers independently of the other HLS components. Significant inverse associations were observed for each 20-unit increase in HLS and IL-6 and TNF-α for participants with hypertension (n = 600; β ± SE = -0.58 ± 0.16; -0.46 ± 0.16, respectively) and with overweight/obesity (n = 743; β ± SE = -0.59 ± 0.13; -0.50 ± 0.14, respectively), but not for those with diabetes (n = 187) or heart disease (n = 192). The HLS was not associated with CRP, after adjustment for potential confounders. Conclusion: Higher adherence to multiple lifestyle behaviors was associated with lower concentrations of inflammatory markers. Because low-grade inflammation may precede chronic diseases, following an overall healthy lifestyle may help lower risk of these diseases.
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U2 - 10.1016/j.numecd.2015.12.004
DO - 10.1016/j.numecd.2015.12.004
M3 - Article
C2 - 26838054
AN - SCOPUS:84959456342
SN - 0939-4753
VL - 26
SP - 178
EP - 184
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 3
ER -