TY - JOUR
T1 - Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis
AU - Nudy, M.
AU - Xie, R.
AU - O’Sullivan, D. M.
AU - Jiang, X.
AU - Appt, S.
AU - Register, T. C.
AU - Kaplan, J. R.
AU - Clarkson, T. B.
AU - Schnatz, P. F.
N1 - Funding Information:
sources for this research and article were research budgets of Wake Forest University Primate Center and The Reading Hospital and Medical Center; original study was supported by National Institutes of Health [HL079421] (J.R.K.); [P01 HL 45666] (T.B.C., J.R.K.). This manuscript is in memory of the deceased author, Dr Thomas B. Clarkson, DVM, who passed away on 1 December. 2015. Dr Clarkson was a wonderful friend, mentor and colleague and is dearly missed. The data were presented in oral form on 5 October 2012 at the NAMS 23rd annual Meeting in Orlando, FL, USA. These data and results, however, have not published in manuscript form.
Funding Information:
T. B. Clarkson, DVM was a member of an advisory committee to Pfizer pharmaceuticals and was supported with a research grant from Pfizer. He was also the recipient of a research grant from Merck. The other authors have no conflicts of interest or competing interests.
Publisher Copyright:
© 2021 International Menopause Society.
PY - 2022
Y1 - 2022
N2 - Objective: The aim of this study is to analyze the association between coronary artery vitamin D receptor (VDR) expression and systemic coronary artery atherosclerosis (CAA) risk factors. Methods: Female cynomolgus monkeys (n = 39) consumed atherogenic diets containing the women’s equivalent of 1000 IU/day of vitamin D3. After 32 months consuming the diets, each monkey underwent surgical menopause. After 32 postmenopausal months, CAA and VDR expression were quantified in the left anterior descending coronary artery. Plasma 25OHD3, lipid profiles and serum monocyte chemotactic protein-1 (MCP-1) were measured. Results: In postmenopausal monkeys receiving atherogenic diets, serum MCP-1 was significantly elevated compared with baseline (482.2 ± 174.2 pg/ml vs. 349.1 ± 163.2 pg/ml, respectively; p < 0.001; d = 0.79) and at the start of menopause (363.4 ± 117.2 pg/ml; p < 0.001; d = 0.80). Coronary VDR expression was inversely correlated with serum MCP-1 (p = 0.042). Additionally, the change of postmenopausal MCP-1 (from baseline to necropsy) was significantly reduced in the group with higher, compared to below the median, VDR expression (p = 0.038). The combination of plasma 25OHD3 and total plasma cholesterol/high-density lipoprotein cholesterol was subsequently broken into low-risk, moderate-risk and high-risk groups; as the risk increased, the VDR quantity decreased (p = 0.04). CAA was not associated with various atherogenic diets. Conclusion: Coronary artery VDR expression was inversely correlated with markers of CAA risk and inflammation, including MCP-1, suggesting that systemic and perhaps local inflammation in the artery may be associated with reduced arterial VDR expression.
AB - Objective: The aim of this study is to analyze the association between coronary artery vitamin D receptor (VDR) expression and systemic coronary artery atherosclerosis (CAA) risk factors. Methods: Female cynomolgus monkeys (n = 39) consumed atherogenic diets containing the women’s equivalent of 1000 IU/day of vitamin D3. After 32 months consuming the diets, each monkey underwent surgical menopause. After 32 postmenopausal months, CAA and VDR expression were quantified in the left anterior descending coronary artery. Plasma 25OHD3, lipid profiles and serum monocyte chemotactic protein-1 (MCP-1) were measured. Results: In postmenopausal monkeys receiving atherogenic diets, serum MCP-1 was significantly elevated compared with baseline (482.2 ± 174.2 pg/ml vs. 349.1 ± 163.2 pg/ml, respectively; p < 0.001; d = 0.79) and at the start of menopause (363.4 ± 117.2 pg/ml; p < 0.001; d = 0.80). Coronary VDR expression was inversely correlated with serum MCP-1 (p = 0.042). Additionally, the change of postmenopausal MCP-1 (from baseline to necropsy) was significantly reduced in the group with higher, compared to below the median, VDR expression (p = 0.038). The combination of plasma 25OHD3 and total plasma cholesterol/high-density lipoprotein cholesterol was subsequently broken into low-risk, moderate-risk and high-risk groups; as the risk increased, the VDR quantity decreased (p = 0.04). CAA was not associated with various atherogenic diets. Conclusion: Coronary artery VDR expression was inversely correlated with markers of CAA risk and inflammation, including MCP-1, suggesting that systemic and perhaps local inflammation in the artery may be associated with reduced arterial VDR expression.
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U2 - 10.1080/13697137.2021.1985992
DO - 10.1080/13697137.2021.1985992
M3 - Article
C2 - 34694941
AN - SCOPUS:85118130534
SN - 1369-7137
VL - 25
SP - 369
EP - 375
JO - Climacteric
JF - Climacteric
IS - 4
ER -