Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal; Ruth Voss; Hamid Al-Mondhiry; Aaron Polliack; John A. Hansen; Marta Siegal; Robert A. Good

doi:10.1016/0002-9343(76)90545-3

Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal, Ruth Voss, Hamid Al-Mondhiry, Aaron Polliack, John A. Hansen, Marta Siegal, Robert A. Good

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

Original language	English (US)
Pages (from-to)	157-166
Number of pages	10
Journal	The American journal of medicine
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(76)90545-3
State	Published - Jan 1976

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1016/0002-9343(76)90545-3

Cite this

@article{4718ab50bf634168a920192bac8ccbe7,

title = "Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease",

abstract = "The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.",

author = "Siegal, {Frederick P.} and Ruth Voss and Hamid Al-Mondhiry and Aaron Polliack and Hansen, {John A.} and Marta Siegal and Good, {Robert A.}",

year = "1976",

month = jan,

doi = "10.1016/0002-9343(76)90545-3",

language = "English (US)",

volume = "60",

pages = "157--166",

journal = "The American journal of medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

AU - Siegal, Frederick P.

AU - Voss, Ruth

AU - Al-Mondhiry, Hamid

AU - Polliack, Aaron

AU - Hansen, John A.

AU - Siegal, Marta

AU - Good, Robert A.

PY - 1976/1

Y1 - 1976/1

N2 - The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

AB - The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

UR - http://www.scopus.com/inward/record.url?scp=0017288374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017288374&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(76)90545-3

DO - 10.1016/0002-9343(76)90545-3

M3 - Article

C2 - 1082714

AN - SCOPUS:0017288374

SN - 0002-9343

VL - 60

SP - 157

EP - 166

JO - The American journal of medicine

JF - The American journal of medicine

IS - 1

ER -

Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this