TY - JOUR
T1 - Association of a low density lipoprotein receptor microsatellite variant with obesity
AU - Rutherford, S.
AU - Nyholt, D. R.
AU - Curtain, R. P.
AU - Quinlan, S. R.
AU - Gaffney, P. T.
AU - Morris, B. J.
AU - Griffiths, L. R.
N1 - Funding Information:
This work was supported by grants from the National Health and Medical Research Council of Australia and Griffith University. We wish to thank Dr A Green and volunteers from the Nambour Skin Cancer Trial, general practitioners and those individuals who responded to media releases for providing blood samples. We would also like to thank Dr Clyde Wild for help with statistical analysis and Ms Brenda Cheung for ABI fractionation of PCR products.
PY - 1997
Y1 - 1997
N2 - OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.
AB - OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.
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U2 - 10.1038/sj.ijo.0800512
DO - 10.1038/sj.ijo.0800512
M3 - Article
C2 - 9368827
AN - SCOPUS:0030809211
SN - 0307-0565
VL - 21
SP - 1032
EP - 1037
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 11
ER -