Association of a low density lipoprotein receptor microsatellite variant with obesity

S. Rutherford; D. R. Nyholt; R. P. Curtain; S. R. Quinlan; P. T. Gaffney; B. J. Morris; L. R. Griffiths

doi:10.1038/sj.ijo.0800512

Association of a low density lipoprotein receptor microsatellite variant with obesity

S. Rutherford
, D. R. Nyholt
, R. P. Curtain
, S. R. Quinlan
, P. T. Gaffney
, B. J. Morris
, L. R. Griffiths

Biobehavioral Health

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m², and 163 lean individuals, defined as a BMI < 26 kg/m². MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ² = 12.3, P = 0.002), but not in males (χ² = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.

Original language	English (US)
Pages (from-to)	1032-1037
Number of pages	6
Journal	International Journal of Obesity
Volume	21
Issue number	11
DOIs	https://doi.org/10.1038/sj.ijo.0800512
State	Published - 1997

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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title = "Association of a low density lipoprotein receptor microsatellite variant with obesity",

abstract = "OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.",

author = "S. Rutherford and Nyholt, \{D. R.\} and Curtain, \{R. P.\} and Quinlan, \{S. R.\} and Gaffney, \{P. T.\} and Morris, \{B. J.\} and Griffiths, \{L. R.\}",

note = "Funding Information: This work was supported by grants from the National Health and Medical Research Council of Australia and Griffith University. We wish to thank Dr A Green and volunteers from the Nambour Skin Cancer Trial, general practitioners and those individuals who responded to media releases for providing blood samples. We would also like to thank Dr Clyde Wild for help with statistical analysis and Ms Brenda Cheung for ABI fractionation of PCR products.",

year = "1997",

doi = "10.1038/sj.ijo.0800512",

language = "English (US)",

volume = "21",

pages = "1032--1037",

journal = "International Journal of Obesity",

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T1 - Association of a low density lipoprotein receptor microsatellite variant with obesity

AU - Rutherford, S.

AU - Nyholt, D. R.

AU - Curtain, R. P.

AU - Quinlan, S. R.

AU - Gaffney, P. T.

AU - Morris, B. J.

AU - Griffiths, L. R.

N1 - Funding Information: This work was supported by grants from the National Health and Medical Research Council of Australia and Griffith University. We wish to thank Dr A Green and volunteers from the Nambour Skin Cancer Trial, general practitioners and those individuals who responded to media releases for providing blood samples. We would also like to thank Dr Clyde Wild for help with statistical analysis and Ms Brenda Cheung for ABI fractionation of PCR products.

PY - 1997

Y1 - 1997

N2 - OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.

AB - OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.

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Association of a low density lipoprotein receptor microsatellite variant with obesity

Abstract

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