Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

Muhammad Rizwanulhaq Khawaja; Fawad Taj; Usman Ahmad; Danish Saleheen; Tazeen Jafar; Philippe M. Frossard

doi:10.1016/j.ijcard.2006.04.019

Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

Muhammad Rizwanulhaq Khawaja, Fawad Taj, Usman Ahmad, Danish Saleheen, Tazeen Jafar, Philippe M. Frossard

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13 Scopus citations

Abstract

This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 normotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.

Original language	English (US)
Pages (from-to)	113-115
Number of pages	3
Journal	International Journal of Cardiology
Volume	116
Issue number	1
DOIs	https://doi.org/10.1016/j.ijcard.2006.04.019
State	Published - Mar 2 2007

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2006.04.019

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abstract = "This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 normotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.",

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AU - Khawaja, Muhammad Rizwanulhaq

AU - Taj, Fawad

AU - Ahmad, Usman

AU - Saleheen, Danish

AU - Jafar, Tazeen

AU - Frossard, Philippe M.

PY - 2007/3/2

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Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

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