Association of IGF axis hormones with waist-to-hip ratio varies by physical activity

Kathryn H. Schmitz, Dawei Xie, Valerie Teal, Rachel Ballard-Barbash, David Berrigan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background/Aim: Insulin-like growth factor (IGF) axis hormones are associated with multiple chronic diseases. Reports of the relationship between adiposity and IGF-axis hormones vary widely. This study hypothesized that physical activity levels modify the association of IGF axis hormones with adiposity. Patients and Methods: Data from NHANES III were used to assess whether associations of adiposity, namely waist-to-hip ratio (WHR), with IGF axis hormones varied according to physical activity. Results: Among those in the lowest physical activity quintile, WHR had a substantive inverse association: bioavailable IGF-I was 16% lower among those in the highest versus the lowest WHR quintiles among the least active subjects (p<0.001). By comparison, among those in the highest physical activity quintile, IGF-I did not vary by WHR. Conclusion: The association of bioavailable IGF-1 with central adiposity differs among active versus inactive adults in the USA. This has relevance to understanding previously reported benefits of physical activity among overweight individuals.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalIn Vivo
Issue number2
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology


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