Association of thyroid nodule size and Bethesda class with rate of malignant disease

Marcus J. Magister, Irina Chaikhoutdinov, Eric Schaefer, Nicole Williams, Brian Saunders, David Goldenberg

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


IMPORTANCE The ability to accurately stratify patients with thyroid nodules (TNs) preoperatively is imperative because most TNs are benign. The reliability of fine-needle aspiration biopsy (FNAB) in large TNs has been questioned in recent literature. OBJECTIVE To determine whether TN size affects the reliability of FNAB results, and to determine the rates of malignant disease of each Bethesda class at Penn State Medical Center. DESIGN, SETTING, AND PARTICIPANTS Retrospective electronic medical record review of patients undergoing FNAB followed by thyroidectomy from March 2010 through December 2013 at an academic, tertiary referral center. A total of 297 patients with 326 TNs were identified as part of a consecutive series. MAIN OUTCOMES AND MEASURES The primary outcomewas to determine the rate of malignant disease of TNs smaller than 3.0 cmor 3.0 cm or larger and of each Bethesda class. Statistical analysis included χ2 tests. The secondary outcome was to develop logistic regression models to estimate the probability of malignant disease on final pathologic diagnosis as predicted by TN size as well as TN size in conjunction with Bethesda class. RESULTS Of the 297 patients, 233 were female (78.4%). The mean (SD) age was 51.0 (15.4) years. Of the 326 TNs, 143 were malignant on surgical histopathologic analysis (43.7%). The mean TN size was 2.0 (1.4) cm. Rates of malignant disease for Bethesda classes 1 to 6 were 0% (95%CI, 0%-26.0%), 6.0% (95%CI, 1.7%-14.6%), 30.2%(95%CI, 18.3%-44.3%), 23.5% (95%CI, 14.8%-34.2%), 72.4%(95%CI, 52.8%-87.3%), and 98.8% (95%CI, 93.5%-99.9%), respectively. Overall sensitivity and specificity (excluding class 1 TNs) were 97.2%and 36.8%, respectively. The false-negative rate of benign cytologic results was 6.0%(95%CI, 1.7%-14.6%); only 1 false-negative result occurred in TNs 3.0 cmor greater. Of the TNs smaller than 3.0 cm, 48.4%were malignant compared with 33.3%of TNs 3.0 cmor greater (P =.049). Both Bethesda class and TN size were significant variables (P <.05) within our logistic regression models indicating that higher Bethesda class and TN size smaller than about 2.0 cmwere associated with increased probabilities of malignant disease. CONCLUSIONS AND RELEVANCE Our results suggest that smaller TNs (smaller than about 2.0 cm) are associated with increased probabilities of malignant disease irrespective of Bethesda class. Routine diagnostic thyroid lobectomy solely owing to TN size of 3.0 cm or greater need not be performed.

Original languageEnglish (US)
Pages (from-to)1089-1095
Number of pages7
JournalJAMA Otolaryngology - Head and Neck Surgery
Issue number12
StatePublished - Dec 2015

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


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