TY - JOUR
T1 - Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
AU - CAAPA
AU - Daya, Michelle
AU - Rafaels, Nicholas
AU - Brunetti, Tonya M.
AU - Chavan, Sameer
AU - Levin, Albert M.
AU - Shetty, Aniket
AU - Gignoux, Christopher R.
AU - Boorgula, Meher Preethi
AU - Wojcik, Genevieve
AU - Campbell, Monica
AU - Vergara, Candelaria
AU - Torgerson, Dara G.
AU - Ortega, Victor E.
AU - Doumatey, Ayo
AU - Johnston, Henry Richard
AU - Acevedo, Nathalie
AU - Araujo, Maria Ilma
AU - Avila, Pedro C.
AU - Belbin, Gillian
AU - Bleecker, Eugene
AU - Bustamante, Carlos
AU - Caraballo, Luis
AU - Cruz, Alvaro
AU - Dunston, Georgia M.
AU - Eng, Celeste
AU - Faruque, Mezbah U.
AU - Ferguson, Trevor S.
AU - Figueiredo, Camila
AU - Ford, Jean G.
AU - Gan, Weiniu
AU - Gourraud, Pierre Antoine
AU - Hansel, Nadia N.
AU - Hernandez, Ryan D.
AU - Herrera-Paz, Edwin Francisco
AU - Jiménez, Silvia
AU - Kenny, Eimear E.
AU - Knight-Madden, Jennifer
AU - Kumar, Rajesh
AU - Lange, Leslie A.
AU - Lange, Ethan M.
AU - Lizee, Antoine
AU - Maul, Pissamai
AU - Maul, Trevor
AU - Mayorga, Alvaro
AU - Meyers, Deborah
AU - Nicolae, Dan L.
AU - O’Connor, Timothy D.
AU - Oliveira, Ricardo Riccio
AU - Olopade, Christopher O.
AU - Szpiech, Zachary A.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
AB - Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
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U2 - 10.1038/s41467-019-08469-7
DO - 10.1038/s41467-019-08469-7
M3 - Article
C2 - 30787307
AN - SCOPUS:85061908861
SN - 2041-1723
VL - 10
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 880
ER -