Associations between hair manganese levels and cognitive, language, and motor development in preschool children from montevideo, uruguay

Stephanie M. Rink; Graciela Ardoino; Elena I. Queirolo; Daniela Cicariello; Nelly Mañay; Katarzyna Kordas

doi:10.1080/19338244.2012.725229

Associations between hair manganese levels and cognitive, language, and motor development in preschool children from montevideo, uruguay

Stephanie M. Rink, Graciela Ardoino, Elena I. Queirolo, Daniela Cicariello, Nelly Mañay, Katarzyna Kordas

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 - 0.74 and 10.1 - 10.5 ?g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.

Original language	English (US)
Pages (from-to)	46-54
Number of pages	9
Journal	Archives of Environmental and Occupational Health
Volume	69
Issue number	1
DOIs	https://doi.org/10.1080/19338244.2012.725229
State	Published - 2014

All Science Journal Classification (ASJC) codes

Toxicology
General Environmental Science
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1080/19338244.2012.725229

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title = "Associations between hair manganese levels and cognitive, language, and motor development in preschool children from montevideo, uruguay",

abstract = "Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 - 0.74 and 10.1 - 10.5 ?g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.",

author = "Rink, {Stephanie M.} and Graciela Ardoino and Queirolo, {Elena I.} and Daniela Cicariello and Nelly Ma{\~n}ay and Katarzyna Kordas",

note = "Funding Information: This study was funded by a seed grant from the Children, Youth and Families Consortium, Pennsylvania State University, University Park, Pennsylvania.",

year = "2014",

doi = "10.1080/19338244.2012.725229",

language = "English (US)",

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T1 - Associations between hair manganese levels and cognitive, language, and motor development in preschool children from montevideo, uruguay

AU - Rink, Stephanie M.

AU - Ardoino, Graciela

AU - Queirolo, Elena I.

AU - Cicariello, Daniela

AU - Mañay, Nelly

AU - Kordas, Katarzyna

N1 - Funding Information: This study was funded by a seed grant from the Children, Youth and Families Consortium, Pennsylvania State University, University Park, Pennsylvania.

PY - 2014

Y1 - 2014

N2 - Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 - 0.74 and 10.1 - 10.5 ?g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.

AB - Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 - 0.74 and 10.1 - 10.5 ?g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.

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Associations between hair manganese levels and cognitive, language, and motor development in preschool children from montevideo, uruguay

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