Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: A community-based cohort study

Chen Mao, Jin Qiu Yuan, Yue Bin Lv, Xiang Gao, Zhao Xue Yin, Virginia Byers Kraus, Jie Si Luo, Choy Lye Chei, David Bruce Matchar, Yi Zeng, Xiao Ming Shi

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Background: Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults. Methods: This is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). We included individuals aged 65 or above and with plasma SOD activity and/or MDA tests at baseline. We evaluated the hazard ratios (HRs) and 95% confidence intervals (CIs) by multivariable Cox models. Results: We documented 858 deaths during six years of follow-up. There was a significant interaction effect of sex with the association between SOD activity and mortality (P < 0.001). Compared with the lowest quintile, the risk of all-cause mortality was inversely associated with increasing quintiles of plasma SOD activity in women(P-trend< 0.001), with adjusted HRs for the second through fifth quintiles of 0.73 (95% CI 0.53-1.02), 0.52(95% CI 0.38-0.72), 0.53(95% CI 0.39-0.73), and 0.48(95% CI 0.35-0.66). There were no significant associations between SOD activity and mortality in men (P-trend = 0.64), and between MDA and mortality in all participants (P-trend = 0.79). Conclusions: Increased activity of SOD was independently associated with lower all-cause mortality in older women but not in men. This epidemiological study lent support for the free radical/oxidative stress theory of aging.

Original languageEnglish (US)
Article number104
JournalBMC Geriatrics
Volume19
Issue number1
DOIs
StatePublished - Apr 15 2019

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: A community-based cohort study'. Together they form a unique fingerprint.

Cite this