TY - JOUR
T1 - Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults
AU - WU, Bing
AU - LYU, Yue Bin
AU - CAO, Zhao Jin
AU - WEI, Yuan
AU - SHI, Wan Ying
AU - GAO, Xiang
AU - ZHOU, Jin Hui
AU - KRAUS, Virginia Byers
AU - ZHAO, Feng
AU - CHEN, Xin
AU - LU, Feng
AU - ZHANG, Ming Yuan
AU - LIU, Ying Chun
AU - TAN, Qi Yue
AU - SONG, Shi Xun
AU - QU, Ying Li
AU - ZHENG, Xu Lin
AU - SHEN, Chong
AU - MAO, Chen
AU - SHI, Xiao Ming
N1 - Publisher Copyright:
© 2021 The Editorial Board of Biomedical and Environmental Sciences
PY - 2021/11
Y1 - 2021/11
N2 - Objective: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. Methods: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment. Results: The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio (OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI): 1.86–3.50]. Compared with individuals in the first quartile (Q1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q2, Q3, and Q4) were 0.75 (95% CI: 0.58–0.96), 0.59 (95% CI: 0.44–0.79), and 0.62 (95% CI: 0.45–0.8), respectively. Compared with individuals in Q1 of handgrip strength, the adjusted ORs for Q2, Q3, and Q4 were 0.49 (95% CI: 0.38–0.62), 0.31 (95% CI: 0.23–0.41), and 0.30 (95% CI: 0.21–0.44), respectively. Conclusion: Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.
AB - Objective: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. Methods: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment. Results: The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio (OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI): 1.86–3.50]. Compared with individuals in the first quartile (Q1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q2, Q3, and Q4) were 0.75 (95% CI: 0.58–0.96), 0.59 (95% CI: 0.44–0.79), and 0.62 (95% CI: 0.45–0.8), respectively. Compared with individuals in Q1 of handgrip strength, the adjusted ORs for Q2, Q3, and Q4 were 0.49 (95% CI: 0.38–0.62), 0.31 (95% CI: 0.23–0.41), and 0.30 (95% CI: 0.21–0.44), respectively. Conclusion: Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.
UR - http://www.scopus.com/inward/record.url?scp=85121516162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121516162&partnerID=8YFLogxK
U2 - 10.3967/bes2021.119
DO - 10.3967/bes2021.119
M3 - Article
C2 - 34955146
AN - SCOPUS:85121516162
SN - 0895-3988
VL - 34
SP - 859
EP - 870
JO - Biomedical and Environmental Sciences
JF - Biomedical and Environmental Sciences
IS - 11
ER -
