Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults

Bing WU, Yue Bin LYU, Zhao Jin CAO, Yuan WEI, Wan Ying SHI, Xiang GAO, Jin Hui ZHOU, Virginia Byers KRAUS, Feng ZHAO, Xin CHEN, Feng LU, Ming Yuan ZHANG, Ying Chun LIU, Qi Yue TAN, Shi Xun SONG, Ying Li QU, Xu Lin ZHENG, Chong SHEN, Chen MAO, Xiao Ming SHI

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. Methods: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment. Results: The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio (OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI): 1.86–3.50]. Compared with individuals in the first quartile (Q1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q2, Q3, and Q4) were 0.75 (95% CI: 0.58–0.96), 0.59 (95% CI: 0.44–0.79), and 0.62 (95% CI: 0.45–0.8), respectively. Compared with individuals in Q1 of handgrip strength, the adjusted ORs for Q2, Q3, and Q4 were 0.49 (95% CI: 0.38–0.62), 0.31 (95% CI: 0.23–0.41), and 0.30 (95% CI: 0.21–0.44), respectively. Conclusion: Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.

Original languageEnglish (US)
Pages (from-to)859-870
Number of pages12
JournalBiomedical and Environmental Sciences
Volume34
Issue number11
DOIs
StatePublished - Nov 2021

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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