TY - JOUR
T1 - Asymmetry in icosahedral viruses
AU - Goetschius, Daniel J.
AU - Parrish, Colin R.
AU - Hafenstein, Susan
N1 - Funding Information:
This work was funded in part by the Pennsylvania Department of Health CURE funds, Huck Institutes at The Pennsylvania State University , and by the Office of the Director, National Institutes of Health , under Award Numbers 1 R01 AI107121-01 (SH), R01 AI092571 (CRP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
This work was funded in part by the Pennsylvania Department of Health CURE funds, Huck Institutes at The Pennsylvania State University, and by the Office of the Director, National Institutes of Health, under Award Numbers 1 R01 AI107121-01 (SH), R01 AI092571 (CRP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/6
Y1 - 2019/6
N2 - Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.
AB - Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.
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U2 - 10.1016/j.coviro.2019.05.006
DO - 10.1016/j.coviro.2019.05.006
M3 - Review article
C2 - 31255982
AN - SCOPUS:85067784440
SN - 1879-6257
VL - 36
SP - 67
EP - 73
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -