Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl; Katherine M. Aird

doi:10.3389/fonc.2017.00291

Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl, Katherine M. Aird

Research output: Contribution to journal › Short survey › peer-review

27 Scopus citations

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

Original language	English (US)
Article number	291
Journal	Frontiers in Oncology
Volume	7
Issue number	NOV
DOIs	https://doi.org/10.3389/fonc.2017.00291
State	Published - Nov 29 2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer",

abstract = "The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.",

author = "Dahl, {Erika S.} and Aird, {Katherine M.}",

note = "Funding Information: We will like to thank the members of the Aird lab for their thoughtful comments. In addition, we would like to thank Benjamin G. Bitler for generously providing his mitochondria graphic. ED is supported by the Biomedical Sciences Graduate Program at Pennsylvania State College of Medicine. KA is supported by an NIH/NCI grant (R00CA194309). Publisher Copyright: {\textcopyright} 2017 Dahl and Aird.",

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doi = "10.3389/fonc.2017.00291",

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AU - Aird, Katherine M.

N1 - Funding Information: We will like to thank the members of the Aird lab for their thoughtful comments. In addition, we would like to thank Benjamin G. Bitler for generously providing his mitochondria graphic. ED is supported by the Biomedical Sciences Graduate Program at Pennsylvania State College of Medicine. KA is supported by an NIH/NCI grant (R00CA194309). Publisher Copyright: © 2017 Dahl and Aird.

PY - 2017/11/29

Y1 - 2017/11/29

N2 - The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

AB - The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

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Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Abstract

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