Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl; Katherine M. Aird

doi:10.3389/fonc.2017.00291

Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl, Katherine M. Aird

Research output: Contribution to journal › Short survey › peer-review

34 Scopus citations

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

Original language	English (US)
Article number	291
Journal	Frontiers in Oncology
Volume	7
Issue number	NOV
DOIs	https://doi.org/10.3389/fonc.2017.00291
State	Published - Nov 29 2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer",

abstract = "The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.",

author = "Dahl, {Erika S.} and Aird, {Katherine M.}",

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AU - Dahl, Erika S.

AU - Aird, Katherine M.

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Y1 - 2017/11/29

N2 - The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

AB - The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

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JO - Frontiers in Oncology

JF - Frontiers in Oncology

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ER -

Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Abstract

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