TY - JOUR
T1 - ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes
AU - Tang, Zhenyuan
AU - Takahashi, Yoshinori
AU - Wang, Hong Gang
N1 - Funding Information:
This work was supported by the NIH grants GM127954 and CA222349, the Hyundai Hope On Wheels, the Four Diamonds, and the Lois High Berstler Research Endowment Fund.
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/12/2
Y1 - 2019/12/2
N2 - The mechanism by which ATG2 (ATG2A and ATG2B in mammals) regulates autophagosome biogenesis remains largely unknown. In our recent study, we showed that ATG2A translocates to the mitochondria-associated ER membranes (MAM) to promote phagophore growth during nutrient starvation. Mechanistically, the mitochondrial translocase TOMM40 binds to a C-terminal domain of ATG2A, termed the MAM localization domain (MLD), and mediates its MAM translocation in a manner dependent on the TOMM receptor TOMM70. Moreover, ATG2A associates with ATG9A through its N-terminal domain and this interaction is required for phagophore expansion and efficient autophagic flux. These observations suggest that ATG2 operates a mechanism for phagophore expansion at the MAM through the TOMM40-TOMM70 complex and ATG9 during autophagy.
AB - The mechanism by which ATG2 (ATG2A and ATG2B in mammals) regulates autophagosome biogenesis remains largely unknown. In our recent study, we showed that ATG2A translocates to the mitochondria-associated ER membranes (MAM) to promote phagophore growth during nutrient starvation. Mechanistically, the mitochondrial translocase TOMM40 binds to a C-terminal domain of ATG2A, termed the MAM localization domain (MLD), and mediates its MAM translocation in a manner dependent on the TOMM receptor TOMM70. Moreover, ATG2A associates with ATG9A through its N-terminal domain and this interaction is required for phagophore expansion and efficient autophagic flux. These observations suggest that ATG2 operates a mechanism for phagophore expansion at the MAM through the TOMM40-TOMM70 complex and ATG9 during autophagy.
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U2 - 10.1080/15548627.2019.1666594
DO - 10.1080/15548627.2019.1666594
M3 - Comment/debate
C2 - 31512567
AN - SCOPUS:85073836072
SN - 1554-8627
VL - 15
SP - 2165
EP - 2166
JO - Autophagy
JF - Autophagy
IS - 12
ER -