TY - JOUR
T1 - ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes
AU - Fonseca, Luciana Mascarenhas
AU - Beeri, Michal Schnaider
AU - Hawks, Zoë W.
AU - Jung, Lanee
AU - Cleveland, Michael
AU - Delgado, Nikki
AU - Bulger, Jane
AU - Grinspoon, Elizabeth
AU - Janess, Kamille
AU - Sliwinski, Martin J.
AU - Weinstock, Ruth S.
AU - Chhatwal, Jasmeer P.
AU - Kivisäkk, Pia
AU - Germine, Laura Thi
AU - Chaytor, Naomi S.
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/10/1
Y1 - 2024/10/1
N2 - INTRODUCTION: Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D). METHODS: Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study (N = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self-administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g., kidney disease), and glycemic indices. RESULTS: Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β = 0.261; p = 0.007; GFAP: β = 0.175, p = 0.036), and higher β-amyloid 42/40 ratio was associated with better vocabulary (β = 0.260, p = 0.009). Discussion: Digital cognitive performance was associated with several ATN plasma biomarkers in T1D adults. Prospective studies are needed to understand the utility of these biomarkers in T1D. Highlights: There is an increase in life expectancy for individuals with type 1 diabetes (T1D). Few studies investigate the relationship between T1D and neurodegeneration. We characterize the relation between ATN plasma biomarkers and cognitive function. Digital cognitive performance was associated with plasma biomarkers in T1D adults.
AB - INTRODUCTION: Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D). METHODS: Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study (N = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self-administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g., kidney disease), and glycemic indices. RESULTS: Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β = 0.261; p = 0.007; GFAP: β = 0.175, p = 0.036), and higher β-amyloid 42/40 ratio was associated with better vocabulary (β = 0.260, p = 0.009). Discussion: Digital cognitive performance was associated with several ATN plasma biomarkers in T1D adults. Prospective studies are needed to understand the utility of these biomarkers in T1D. Highlights: There is an increase in life expectancy for individuals with type 1 diabetes (T1D). Few studies investigate the relationship between T1D and neurodegeneration. We characterize the relation between ATN plasma biomarkers and cognitive function. Digital cognitive performance was associated with plasma biomarkers in T1D adults.
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U2 - 10.1002/dad2.70029
DO - 10.1002/dad2.70029
M3 - Article
C2 - 39445343
AN - SCOPUS:85206980062
SN - 2352-8729
VL - 16
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 4
M1 - e70029
ER -
