ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

Pawel Licznerski; Han A. Park; Harshvardhan Rolyan; Rongmin Chen; Nelli Mnatsakanyan; Paige Miranda; Morven Graham; Jing Wu; Nicole Cruz-Reyes; Nikita Mehta; Sana Sohail; Jorge Salcedo; Erin Song; Charles Effman; Samuel Effman; Lucas Brandao; Gulan N. Xu; Amber Braker; Valentin K. Gribkoff; Richard J. Levy; Elizabeth A. Jonas

doi:10.1016/j.cell.2020.07.008

ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

Pawel Licznerski
, Han A. Park
, Harshvardhan Rolyan
, Rongmin Chen
, Nelli Mnatsakanyan
, Paige Miranda
, Morven Graham
, Jing Wu
, Nicole Cruz-Reyes
, Nikita Mehta
, Sana Sohail
, Jorge Salcedo
, Erin Song
, Charles Effman
, Samuel Effman
, Lucas Brandao
, Gulan N. Xu
, Amber Braker
, Valentin K. Gribkoff
, Richard J. Levy

Elizabeth A. Jonas

Department of Cell and Biological Systems

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Lack of FMRP in Fragile X neurons is associated with a leak in the ATP synthase, the blockade of which normalizes cellular and behavioral disease phenotypes.

Original language	English (US)
Pages (from-to)	1170-1185.e9
Journal	Cell
Volume	182
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.07.008
State	Published - Sep 3 2020

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.07.008

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Licznerski, P., Park, H. A., Rolyan, H., Chen, R., Mnatsakanyan, N., Miranda, P., Graham, M., Wu, J., Cruz-Reyes, N., Mehta, N., Sohail, S., Salcedo, J., Song, E., Effman, C., Effman, S., Brandao, L., Xu, G. N., Braker, A., Gribkoff, V. K., ... Jonas, E. A. (2020). ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome. Cell, 182(5), 1170-1185.e9. https://doi.org/10.1016/j.cell.2020.07.008

@article{59531c46cd71490aba628211e2b2381b,

title = "ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome",

abstract = "Lack of FMRP in Fragile X neurons is associated with a leak in the ATP synthase, the blockade of which normalizes cellular and behavioral disease phenotypes.",

author = "Pawel Licznerski and Park, \{Han A.\} and Harshvardhan Rolyan and Rongmin Chen and Nelli Mnatsakanyan and Paige Miranda and Morven Graham and Jing Wu and Nicole Cruz-Reyes and Nikita Mehta and Sana Sohail and Jorge Salcedo and Erin Song and Charles Effman and Samuel Effman and Lucas Brandao and Xu, \{Gulan N.\} and Amber Braker and Gribkoff, \{Valentin K.\} and Levy, \{Richard J.\} and Jonas, \{Elizabeth A.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

day = "3",

doi = "10.1016/j.cell.2020.07.008",

language = "English (US)",

volume = "182",

pages = "1170--1185.e9",

journal = "Cell",

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Licznerski, P, Park, HA, Rolyan, H, Chen, R, Mnatsakanyan, N, Miranda, P, Graham, M, Wu, J, Cruz-Reyes, N, Mehta, N, Sohail, S, Salcedo, J, Song, E, Effman, C, Effman, S, Brandao, L, Xu, GN, Braker, A, Gribkoff, VK, Levy, RJ & Jonas, EA 2020, 'ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome', Cell, vol. 182, no. 5, pp. 1170-1185.e9. https://doi.org/10.1016/j.cell.2020.07.008

TY - JOUR

T1 - ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

AU - Licznerski, Pawel

AU - Park, Han A.

AU - Rolyan, Harshvardhan

AU - Chen, Rongmin

AU - Mnatsakanyan, Nelli

AU - Miranda, Paige

AU - Graham, Morven

AU - Wu, Jing

AU - Cruz-Reyes, Nicole

AU - Mehta, Nikita

AU - Sohail, Sana

AU - Salcedo, Jorge

AU - Song, Erin

AU - Effman, Charles

AU - Effman, Samuel

AU - Brandao, Lucas

AU - Xu, Gulan N.

AU - Braker, Amber

AU - Gribkoff, Valentin K.

AU - Levy, Richard J.

AU - Jonas, Elizabeth A.

PY - 2020/9/3

Y1 - 2020/9/3

N2 - Lack of FMRP in Fragile X neurons is associated with a leak in the ATP synthase, the blockade of which normalizes cellular and behavioral disease phenotypes.

AB - Lack of FMRP in Fragile X neurons is associated with a leak in the ATP synthase, the blockade of which normalizes cellular and behavioral disease phenotypes.

UR - https://www.scopus.com/pages/publications/85090000245

UR - https://www.scopus.com/pages/publications/85090000245#tab=citedBy

U2 - 10.1016/j.cell.2020.07.008

DO - 10.1016/j.cell.2020.07.008

M3 - Article

C2 - 32795412

AN - SCOPUS:85090000245

SN - 0092-8674

VL - 182

SP - 1170-1185.e9

JO - Cell

JF - Cell

IS - 5

ER -

ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

Abstract

All Science Journal Classification (ASJC) codes

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