TY - JOUR
T1 - ATP synthase c-subunit ring as the channel of mitochondrial permeability transition
T2 - Regulator of metabolism in development and degeneration
AU - Mnatsakanyan, Nelli
AU - Jonas, Elizabeth Ann
N1 - Funding Information:
Work was supported by National Institutes of Health, National Institute of Neurological Disorders and Stroke Grants NS045876, NS112706, NS081746 (to E.A.J.), National Institutes of Aging Grant K01AG054734 (to N.M.), U.S.A.
Funding Information:
Work was supported by National Institutes of Health , National Institute of Neurological Disorders and Stroke Grants NS045876 , NS112706 , NS081746 (to E.A.J.), National Institutes of Aging Grant K01AG054734 (to N.M.), U.S.A.
Publisher Copyright:
© 2020 The Authors
PY - 2020/7
Y1 - 2020/7
N2 - The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.
AB - The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.
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U2 - 10.1016/j.yjmcc.2020.05.013
DO - 10.1016/j.yjmcc.2020.05.013
M3 - Article
C2 - 32461058
AN - SCOPUS:85085549893
SN - 0022-2828
VL - 144
SP - 109
EP - 118
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
ER -