TY - JOUR
T1 - Attention alters neural responses to evocative faces in behaviorally inhibited adolescents
AU - Pérez-Edgar, Koraly
AU - Roberson-Nay, Roxann
AU - Hardin, Michael G.
AU - Poeth, Kaitlin
AU - Guyer, Amanda E.
AU - Nelson, Eric E.
AU - McClure, Erin B.
AU - Henderson, Heather A.
AU - Fox, Nathan A.
AU - Pine, Daniel S.
AU - Ernst, Monique
N1 - Funding Information:
This work was supported by the National Institute of Mental Health (K01 MH073569-01 to KPE) and the National Institute of Child Health and Human Development (R01 HD044651-01 to NAF). We would like to thank S. Barton for assistance in participant recruitment, H. Iwamoto and S. Fromm for technical support, and the clinical staff for the psychiatric evaluations of the participants. We are deeply indebted to the families who have participated and continue to participate in this research.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Behavioral inhibition (BI) is a risk factor for anxiety disorders. While the two constructs bear behavioral similarities, previous work has not extended these parallels to the neural level. This study examined amygdala reactivity during a task previously used with clinically anxious adolescents. Adolescents were selected for enduring patterns of BI or non-inhibition (BN). We examined amygdala response to evocative emotion faces in BI (N = 10, mean 12.8 years) and BN (N = 17, mean 12.5 years) adolescents while systematically manipulating attention. Analyses focused on amygdala response during subjective ratings of internal fear (constrained attention) and passive viewing (unconstrained attention) during the presentation of emotion faces (Happy, Angry, Fearful, and Neutral). BI adolescents, relative to BN adolescents, showed exaggerated amygdala response during subjective fear ratings and deactivation during passive viewing, across all emotion faces. In addition, the BI group showed an abnormally high amygdala response to a task condition marked by novelty and uncertainty (i.e., rating fear state to a Happy face). Perturbations in amygdala function are evident in adolescents temperamentally at risk for anxiety. Attention state alters the underlying pattern of neural processing, potentially mediating the observed behavioral patterns across development. BI adolescents also show a heightened sensitivity to novelty and uncertainty, which has been linked to anxiety. These patterns of reactivity may help sustain early temperamental biases over time and contribute to the observed relation between BI and anxiety.
AB - Behavioral inhibition (BI) is a risk factor for anxiety disorders. While the two constructs bear behavioral similarities, previous work has not extended these parallels to the neural level. This study examined amygdala reactivity during a task previously used with clinically anxious adolescents. Adolescents were selected for enduring patterns of BI or non-inhibition (BN). We examined amygdala response to evocative emotion faces in BI (N = 10, mean 12.8 years) and BN (N = 17, mean 12.5 years) adolescents while systematically manipulating attention. Analyses focused on amygdala response during subjective ratings of internal fear (constrained attention) and passive viewing (unconstrained attention) during the presentation of emotion faces (Happy, Angry, Fearful, and Neutral). BI adolescents, relative to BN adolescents, showed exaggerated amygdala response during subjective fear ratings and deactivation during passive viewing, across all emotion faces. In addition, the BI group showed an abnormally high amygdala response to a task condition marked by novelty and uncertainty (i.e., rating fear state to a Happy face). Perturbations in amygdala function are evident in adolescents temperamentally at risk for anxiety. Attention state alters the underlying pattern of neural processing, potentially mediating the observed behavioral patterns across development. BI adolescents also show a heightened sensitivity to novelty and uncertainty, which has been linked to anxiety. These patterns of reactivity may help sustain early temperamental biases over time and contribute to the observed relation between BI and anxiety.
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U2 - 10.1016/j.neuroimage.2007.02.006
DO - 10.1016/j.neuroimage.2007.02.006
M3 - Article
C2 - 17376704
AN - SCOPUS:34147108781
SN - 1053-8119
VL - 35
SP - 1538
EP - 1546
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -