Attention and executive function are impaired during active standing in postural tachycardia syndrome

Amanda J. Miller; Timothy Sheehan; Kate M. Bourne; Monica Feeley; Amy C. Arnold

doi:10.1016/j.autneu.2020.102692

Attention and executive function are impaired during active standing in postural tachycardia syndrome

Amanda J. Miller, Timothy Sheehan, Kate M. Bourne, Monica Feeley, Amy C. Arnold

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8 Scopus citations

Abstract

Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.

Original language	English (US)
Article number	102692
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	227
DOIs	https://doi.org/10.1016/j.autneu.2020.102692
State	Published - Sep 2020

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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title = "Attention and executive function are impaired during active standing in postural tachycardia syndrome",

abstract = "Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.",

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AU - Miller, Amanda J.

AU - Sheehan, Timothy

AU - Bourne, Kate M.

AU - Feeley, Monica

AU - Arnold, Amy C.

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N2 - Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.

AB - Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.

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Attention and executive function are impaired during active standing in postural tachycardia syndrome

Abstract

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