TY - JOUR
T1 - Attentional ERPs distinguish aging and early Alzheimer's dementia
AU - Lockwood, Colin T.
AU - Vaughn, William
AU - Duffy, Charles J.
N1 - Funding Information:
The authors gratefully acknowledge the contributions of Drs. Roberto Fernandez and Anthony Monacelli to preliminary data collection and analysis. The authors are grateful to Drs. Michael S. Jacob and William K. Page for their comments on earlier versions of the article. Teresa Steffenella collaborated on participant recruitment and data recording. This work was supported by NEI R01-EY022062, NEI P30-EY01319, and R01-NIA AG17596.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10
Y1 - 2018/10
N2 - The early detection of Alzheimer's disease requires our distinguishing it from cognitive aging. Here, we test whether spatial attentional changes might support that distinction. We engaged young normal (YN), older normal (ON), and patients with early Alzheimer's dementia (EAD) in an attentionally cued, self-movement heading discrimination task while we recorded push-button response times and event related potentials. YNs and ONs show the behavioral effects of attentional shifts from the cue to the target, whereas EAD patients did not (p < 0.001). YNs and ONs also show the shifting lateralization of a newly described attentional event related potentials component, whereas EAD patients did not (p < 0.001). Our findings suggest that spatial inattention in EAD patients may contribute to heading direction processing impairments that distinguish them from ONs and undermine their navigational capacity and driving safety.
AB - The early detection of Alzheimer's disease requires our distinguishing it from cognitive aging. Here, we test whether spatial attentional changes might support that distinction. We engaged young normal (YN), older normal (ON), and patients with early Alzheimer's dementia (EAD) in an attentionally cued, self-movement heading discrimination task while we recorded push-button response times and event related potentials. YNs and ONs show the behavioral effects of attentional shifts from the cue to the target, whereas EAD patients did not (p < 0.001). YNs and ONs also show the shifting lateralization of a newly described attentional event related potentials component, whereas EAD patients did not (p < 0.001). Our findings suggest that spatial inattention in EAD patients may contribute to heading direction processing impairments that distinguish them from ONs and undermine their navigational capacity and driving safety.
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U2 - 10.1016/j.neurobiolaging.2018.05.022
DO - 10.1016/j.neurobiolaging.2018.05.022
M3 - Article
C2 - 29960173
AN - SCOPUS:85049030433
SN - 0197-4580
VL - 70
SP - 51
EP - 58
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -