Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan

Jon E. Sprague; Xuemei Huang; Arthi Kanthasamy; David E. Nichols

doi:10.1016/0024-3205(94)00658-X

Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan

Jon E. Sprague, Xuemei Huang, Arthi Kanthasamy, David E. Nichols

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Abstract

Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [³H]- paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced serontonergic terminal degeneration is also discussed.

Original language	English (US)
Pages (from-to)	1193-1198
Number of pages	6
Journal	Life Sciences
Volume	55
Issue number	15
DOIs	https://doi.org/10.1016/0024-3205(94)00658-X
State	Published - 1994

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(94)00658-X

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@article{27b3d1ed879c412da0b883c891dace4b,

title = "Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan",

abstract = "Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]- paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced serontonergic terminal degeneration is also discussed.",

author = "Sprague, {Jon E.} and Xuemei Huang and Arthi Kanthasamy and Nichols, {David E.}",

note = "Funding Information: This work was supported by USPHS Grant DA04758 from the National Institute on Drug Abuse. The authors thank Stewart Frescas for the synthesis of MDMA.",

year = "1994",

doi = "10.1016/0024-3205(94)00658-X",

language = "English (US)",

volume = "55",

pages = "1193--1198",

journal = "Life Sciences",

issn = "0024-3205",

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T1 - Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan

AU - Sprague, Jon E.

AU - Huang, Xuemei

AU - Kanthasamy, Arthi

AU - Nichols, David E.

N1 - Funding Information: This work was supported by USPHS Grant DA04758 from the National Institute on Drug Abuse. The authors thank Stewart Frescas for the synthesis of MDMA.

PY - 1994

Y1 - 1994

N2 - Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]- paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced serontonergic terminal degeneration is also discussed.

AB - Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]- paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced serontonergic terminal degeneration is also discussed.

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Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan

Abstract

All Science Journal Classification (ASJC) codes

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