Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse

Keyphrases

• Vascular Function 100%
• Receptor Tyrosine Kinase 100%
• NADPH Oxidase 100%
• Diabetic Mice 100%
• Tyrosine Kinase Activity 100%
• Mesenteric Resistance Arteries 100%
• Contractile Response 80%
• Endothelium-dependent Relaxation 60%
• Vascular Dysfunction 40%
• NADPH Oxidase Activity 40%
• Incubation 20%
• MRNA Level 20%
• Oxidative Stress 20%
• Acetylcholine 20%
• Phenylephrine 20%
• Vasoconstriction 20%
• NADPH Oxidase 4 (NOX4) 20%
• P22phox 20%
• P47phox 20%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 20%
• Endothelial Nitric Oxide Synthase (eNOS) 20%
• Vasodilatation 20%
• Rho Kinase 20%
• Db Mouse 20%
• Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitor (EGFR-TKI) 20%

Medicine and Dentistry

• Diabetes Mellitus 100%
• Epidermal Growth Factor Receptor 100%
• Protein Tyrosine Kinase 100%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 100%
• Artery Resistance 71%
• Protein Kinase B 14%
• Incubation 14%
• Phenylephrine 14%
• Vasodilatation 14%
• Oxidative Stress 14%
• Acetylcholine 14%
• Vasoconstriction 14%
• Tyrosine-Kinase Inhibitor 14%
• Rho Kinase 14%
• Messenger RNA 14%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate 14%

Biochemistry, Genetics and Molecular Biology

• U46619 71%
• Artery Resistance 71%
• NOX4 14%
• Thromboxane 14%