TY - JOUR
T1 - Automated analysis of stereotypic behavior induced by psychomotor stimulants
AU - Brann, M. R.
AU - Hacker, M.
AU - Finnerty, M.
AU - Ellis, J.
AU - Lenox, R. H.
AU - Ehrlich, Y. H.
N1 - Funding Information:
ACKNOWLEDGEMENTS This work was supported in part by grants DA 02747 from NIDA and CA24543 from NCI. The expert secretarial assistance of Mrs. Ginger McDowell and Ms. Vicki Sanderson is gratefully acknowledged. We would also like to thank Dr. E. Reit for critiquing the manuscript.
PY - 1983/7
Y1 - 1983/7
N2 - A newly developed rotation sensing device has been applied to the continuous monitoring of animal movement. Animals treated with morphine, amphetamine or apomorphine display different stereotypic movements which can be distinguished by the apparatus. Initial studies have indicated that the apparatus is able not only to identify but also to quantitate some measures of stereotypic behavior. For example, the number and direction of rotations (a measure of motor asymmetry), frequency of changes in movement direction (a measure of stereotypic movement) and periods of cessation of movement are affected differentially with acute morphine, apomorphine or amphetamine treatment. Moreover, using this apparatus, morphine was shown to increase the degree of rotational asymmetry of normal animals and of animals with unilateral lesions of the nigrostriatal pathway.
AB - A newly developed rotation sensing device has been applied to the continuous monitoring of animal movement. Animals treated with morphine, amphetamine or apomorphine display different stereotypic movements which can be distinguished by the apparatus. Initial studies have indicated that the apparatus is able not only to identify but also to quantitate some measures of stereotypic behavior. For example, the number and direction of rotations (a measure of motor asymmetry), frequency of changes in movement direction (a measure of stereotypic movement) and periods of cessation of movement are affected differentially with acute morphine, apomorphine or amphetamine treatment. Moreover, using this apparatus, morphine was shown to increase the degree of rotational asymmetry of normal animals and of animals with unilateral lesions of the nigrostriatal pathway.
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U2 - 10.1016/0091-3057(83)90312-X
DO - 10.1016/0091-3057(83)90312-X
M3 - Article
C2 - 6684779
AN - SCOPUS:0020528696
SN - 0091-3057
VL - 19
SP - 57
EP - 62
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 1
ER -