Autoregulated pulsed-DC mode iontophoretic transdermal system

C. Carley, Seth Wolpert, J. K.J. Li

Research output: Contribution to conferencePaperpeer-review


An autoregulated pulsed-DC iontophoretic device with slow turn-on current has been developed. A specialized high-frequency pulse with a duty cycle of 50% or less is used which will reduce skin irritation due to polarization effects. To avoid patient discomfort, current delivery is increased gradually over a two-minute period to allow the skin to adapt to the applied current level. The rate of drug delivery is regulated by controlling the energy of the delivered pulse. For antihypertensive-drug administration, the device has the arterial pressure and continually readjusts delivery rates to keep it close to a desired target value.

Original languageEnglish (US)
Number of pages2
StatePublished - Dec 1 1989
EventProceedings of the Fifteenth Annual Northeast Bioengineering Conference - Boston, MA, USA
Duration: Mar 27 1989Mar 28 1989


OtherProceedings of the Fifteenth Annual Northeast Bioengineering Conference
CityBoston, MA, USA

All Science Journal Classification (ASJC) codes

  • Bioengineering


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