B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model

Wenbin Wu; Ze Xiu Xiao; Donglan Zeng; Feng Huang; Julie Wang; Yanying Liu; Joseph A. Bellanti; Nancy Olsen; Song Guo Zheng

doi:10.1016/j.ymthe.2020.07.002

B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model

Wenbin Wu, Ze Xiu Xiao, Donglan Zeng, Feng Huang, Julie Wang, Yanying Liu, Joseph A. Bellanti, Nancy Olsen, Song Guo Zheng

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Abstract

Recent studies found that mesenchymal stem cells (MSCs), by virtue of their tissue recovery and immunoregulatory properties, have shown a broad prospect for applications in various autoimmune and degenerative diseases. Although the potential therapeutic use of MSCs is considerable, studies and clinical treatment efficacy are preliminary due to the heterogeneity of MSCs. Herein, based on RNA-sequencing (RNA-seq) and single cell sequence properties, we demonstrated that B7-H1 plays an important role in the immunosuppressive function of human gingiva-derived mesenchymal stem cells (GMSCs) in a collagen-induced arthritis murine model that is dependent on STAT3 signaling. Our data offer convincing evidence that B7-H1 expression by GMSCs helps to identify a new subpopulation of MSCs with a greater immunosuppressive property. The approach provides a unique and additional strategy for stem cells-based therapies of autoimmune and other inflammatory diseases.

Original language	English (US)
Pages (from-to)	2417-2429
Number of pages	13
Journal	Molecular Therapy
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/j.ymthe.2020.07.002
State	Published - Nov 4 2020

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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title = "B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model",

abstract = "Recent studies found that mesenchymal stem cells (MSCs), by virtue of their tissue recovery and immunoregulatory properties, have shown a broad prospect for applications in various autoimmune and degenerative diseases. Although the potential therapeutic use of MSCs is considerable, studies and clinical treatment efficacy are preliminary due to the heterogeneity of MSCs. Herein, based on RNA-sequencing (RNA-seq) and single cell sequence properties, we demonstrated that B7-H1 plays an important role in the immunosuppressive function of human gingiva-derived mesenchymal stem cells (GMSCs) in a collagen-induced arthritis murine model that is dependent on STAT3 signaling. Our data offer convincing evidence that B7-H1 expression by GMSCs helps to identify a new subpopulation of MSCs with a greater immunosuppressive property. The approach provides a unique and additional strategy for stem cells-based therapies of autoimmune and other inflammatory diseases.",

author = "Wenbin Wu and Xiao, {Ze Xiu} and Donglan Zeng and Feng Huang and Julie Wang and Yanying Liu and Bellanti, {Joseph A.} and Nancy Olsen and Zheng, {Song Guo}",

note = "Funding Information: This study was in part supported by grants from the National Key R&D Program of China (2017YFA0105801 to Y.Y.L.); Chinese Natural Science Foundation (81901657 to Z.X.X.); the Natural Science Foundation of Guangdong Province (grant number 2014A030308005 to W.B.W.); and NIH R61 AR073409 (to S.G.Z.). Funding Information: This study was in part supported by grants from the National Key R&D Program of China ( 2017YFA0105801 to Y.Y.L.); Chinese Natural Science Foundation ( 81901657 to Z.X.X.); the Natural Science Foundation of Guangdong Province (grant number 2014A030308005 to W.B.W.); and NIH R61 AR073409 (to S.G.Z.). Publisher Copyright: {\textcopyright} 2020 The Author(s)",

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AU - Huang, Feng

AU - Wang, Julie

AU - Liu, Yanying

AU - Bellanti, Joseph A.

AU - Olsen, Nancy

AU - Zheng, Song Guo

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B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model

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