TY - JOUR
T1 - Bariatric Surgery Resistance
T2 - Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness
AU - Gilbertson, Nicole M.
AU - Paisley, Andrew S.
AU - Kranz, Sibylle
AU - Weltman, Arthur
AU - Kirby, Jennifer L.
AU - Hallowell, Peter T.
AU - Malin, Steven K.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Bariatric surgery is an effective and durable treatment for individuals with obesity and its associated comorbidities. However, not all patients meet weight loss and/or cardiometabolic goals following bariatric surgery, suggesting that some people are bariatric surgery resistant. The reason for this resistance is unclear, but potential factors, such as adiposity-derived inflammation, insulin resistance, hyperglycemia, and aerobic fitness prior to surgery, have been related to blunted surgery responsiveness. Exercise, diet, and/or pharmacology are effective at reducing inflammation and improving insulin action as well as physical function. Herein, we present data that supports the novel hypothesis that intervening prior to surgery can enhance disease resolution in people who are resistant to bariatric surgery.
AB - Bariatric surgery is an effective and durable treatment for individuals with obesity and its associated comorbidities. However, not all patients meet weight loss and/or cardiometabolic goals following bariatric surgery, suggesting that some people are bariatric surgery resistant. The reason for this resistance is unclear, but potential factors, such as adiposity-derived inflammation, insulin resistance, hyperglycemia, and aerobic fitness prior to surgery, have been related to blunted surgery responsiveness. Exercise, diet, and/or pharmacology are effective at reducing inflammation and improving insulin action as well as physical function. Herein, we present data that supports the novel hypothesis that intervening prior to surgery can enhance disease resolution in people who are resistant to bariatric surgery.
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U2 - 10.1007/s11695-017-2966-1
DO - 10.1007/s11695-017-2966-1
M3 - Review article
C2 - 29058238
AN - SCOPUS:85031918381
SN - 0960-8923
VL - 27
SP - 3281
EP - 3291
JO - Obesity Surgery
JF - Obesity Surgery
IS - 12
ER -