Basement membrane: Carbohydrates and X-ray diffraction

P. A. Lee, K. Blasey, I. J. Goldstein, G. B. Pierce

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Epithelial basement membrane, synthesized by a parietal yolk sac carcinoma in vitro or in the ascites, is free of connective tissue cells and products. Carbohydrate components of this basement membrane were d-galactose, d-glucose, mannose, fucose, deoxyribose, ribose, glucosamine, and sialic acid. Total carbohydrate content was 9.50%. Galactosamine, and uronic acid were absent. This composition is compatible with previously reported analyses of basement membrane from non-neoplastic tissues. There was similarity in four out of five intensity maxima with high-angle x-ray diffraction when comparing basement membrane and collagen. A collagen or collagen-like structure may therefore be a basic structural element in epithelial basement membrane.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalExperimental and Molecular Pathology
Issue number3
StatePublished - Jun 1969

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry


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