Benefits of pulsatile flow in pediatric cardiopulmonary bypass procedures: From conception to conduction

Akif Undar, D. Palanzo, F. Qiu, T. Alkan-Bozkaya, A. Akcevin, J. Talor, L. Baer, K. Woitas, R. Wise, R. Mccoach, Y. Guan, N. Haines, Shigang Wang, Joseph Clark, John Myers

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


This review on the benefits of pulsatile flow includes not only experimental and clinical data, but also attempts to further illuminate the major factors as to why this debate has continued during the past 55 years. Every single component of the cardiopulmonary bypass (CPB) circuitry is equally important for generating adequate quality of pulsatility, not only the pump. Therefore, translational research is a necessity to select the best components for the circuit. Generation of pulsatile flow depends on an energy gradient; precise quantification in terms of hemodynamic energy levels is, therefore, a necessity, not an option. Comparisons between perfusion modes should be done after these basic steps have been taken. We have also included experimental and clinical data for direct comparisons between the perfusion modes. In addition, we included several suggestions for future clinical trials for other interested investigators.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
StatePublished - Sep 2011

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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