Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis

Kayla J. Krause; David Goldrich; John Gniady

doi:10.1002/lary.30527

Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis

Kayla J. Krause, David Goldrich, John Gniady

Research output: Contribution to journal › Article › peer-review

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Abstract

Recurrent respiratory (RRP) or laryngeal papillomatosis is the result of human papillomavirus-mediated benign tumor growth on the larynx and is challenging to manage. Benralizumab is a monoclonal antibody targeted against the alpha subunit of the IL-5 receptor on eosinophils. A 61-year-old male patient presented with refractory RRP following multiple surgical excisions. His disease course improved substantially when benralizumab was added to his asthma regimen. There is no clear mechanistic role suggested for benralizumab directly treating RRP. This case may represent a novel application of benralizumab as an adjuvant treatment for patients with RRP and comorbid asthma. Laryngoscope, 133:863–865, 2023.

Original language	English (US)
Pages (from-to)	863-865
Number of pages	3
Journal	Laryngoscope
Volume	133
Issue number	4
DOIs	https://doi.org/10.1002/lary.30527
State	Published - Apr 2023

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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10.1002/lary.30527

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title = "Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis",

abstract = "Recurrent respiratory (RRP) or laryngeal papillomatosis is the result of human papillomavirus-mediated benign tumor growth on the larynx and is challenging to manage. Benralizumab is a monoclonal antibody targeted against the alpha subunit of the IL-5 receptor on eosinophils. A 61-year-old male patient presented with refractory RRP following multiple surgical excisions. His disease course improved substantially when benralizumab was added to his asthma regimen. There is no clear mechanistic role suggested for benralizumab directly treating RRP. This case may represent a novel application of benralizumab as an adjuvant treatment for patients with RRP and comorbid asthma. Laryngoscope, 133:863–865, 2023.",

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AB - Recurrent respiratory (RRP) or laryngeal papillomatosis is the result of human papillomavirus-mediated benign tumor growth on the larynx and is challenging to manage. Benralizumab is a monoclonal antibody targeted against the alpha subunit of the IL-5 receptor on eosinophils. A 61-year-old male patient presented with refractory RRP following multiple surgical excisions. His disease course improved substantially when benralizumab was added to his asthma regimen. There is no clear mechanistic role suggested for benralizumab directly treating RRP. This case may represent a novel application of benralizumab as an adjuvant treatment for patients with RRP and comorbid asthma. Laryngoscope, 133:863–865, 2023.

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Benralizumab as an Adjuvant Therapy for Recurrent Laryngeal Papillomatosis

Abstract

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