Benzodiazepine toxicity with profound suppression of the electroencephalogram

Jason P. Stabley, Edward J. Frear, Marvis Wine, Milind J. Kothari

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The authors report the case of a 60-year-old man with respiratory distress secondary to exacerbation of chronic obstructive pulmonary disease, right lower lobe pneumonia, and severe bronchospasm. High doses of lorazepam were given intravenously after failure to control bronchospasm and agitation with bronchodilators and mucolytic agents; the patient was unresponsive to all stimuli while receiving lorazepam. Electroencephalography revealed a profoundly suppressed pattern without accompanying low-voltage fast activity - this was reversible following withdrawal of the lorazepam.

Original languageEnglish (US)
Pages (from-to)435-436
Number of pages2
JournalJournal of the American Osteopathic Association
Issue number7
StatePublished - Jul 2000

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine


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