Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids

Megan L. Povelones

doi:10.1016/j.molbiopara.2014.03.008

Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids

Megan L. Povelones

Penn State Brandywine

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.

Original language	English (US)
Pages (from-to)	53-60
Number of pages	8
Journal	Molecular and biochemical parasitology
Volume	196
Issue number	1
DOIs	https://doi.org/10.1016/j.molbiopara.2014.03.008
State	Published - Aug 1 2014

All Science Journal Classification (ASJC) codes

Parasitology
Molecular Biology

Access to Document

10.1016/j.molbiopara.2014.03.008

Cite this

@article{c65e46e7f7b54aada12759a720dc1f57,

title = "Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids",

abstract = "The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.",

author = "Povelones, {Megan L.}",

year = "2014",

month = aug,

day = "1",

doi = "10.1016/j.molbiopara.2014.03.008",

language = "English (US)",

volume = "196",

pages = "53--60",

journal = "Molecular and biochemical parasitology",

issn = "0166-6851",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Beyond replication

T2 - division and segregation of mitochondrial DNA in kinetoplastids

AU - Povelones, Megan L.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.

AB - The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.

UR - http://www.scopus.com/inward/record.url?scp=85027946210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027946210&partnerID=8YFLogxK

U2 - 10.1016/j.molbiopara.2014.03.008

DO - 10.1016/j.molbiopara.2014.03.008

M3 - Review article

C2 - 24704441

AN - SCOPUS:85027946210

SN - 0166-6851

VL - 196

SP - 53

EP - 60

JO - Molecular and biochemical parasitology

JF - Molecular and biochemical parasitology

IS - 1

ER -

Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this