Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

Santosh K. Misra; Goutam Ghoshal; Tor W. Jensen; Partha S. Ray; Everette C. Burdette; Dipanjan Pan

doi:10.1039/c5ra08977h

Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

Santosh K. Misra
, Goutam Ghoshal
, Tor W. Jensen
, Partha S. Ray
, Everette C. Burdette
, Dipanjan Pan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Herein we report a bi-modal cancer treatment technique using therapeutic ultrasound in the presence of a novel sorafenib loaded nanobubble for hepatocellular carcinoma. Therapeutic ultrasound was used for improving fusion-triggered drug release from nanobubbles leading to enhanced cytotoxicity in HepG2 cells by greater than two folds improvement in IC₅₀ values. This strategy could also be made compatible with catheter-based devices to derive a highly localized treatment approach, a concept that might be extendable to metastatic cancers as well.

Original language	English (US)
Pages (from-to)	63839-63845
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	78
DOIs	https://doi.org/10.1039/c5ra08977h
State	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1039/c5ra08977h

Cite this

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abstract = "Herein we report a bi-modal cancer treatment technique using therapeutic ultrasound in the presence of a novel sorafenib loaded nanobubble for hepatocellular carcinoma. Therapeutic ultrasound was used for improving fusion-triggered drug release from nanobubbles leading to enhanced cytotoxicity in HepG2 cells by greater than two folds improvement in IC50 values. This strategy could also be made compatible with catheter-based devices to derive a highly localized treatment approach, a concept that might be extendable to metastatic cancers as well.",

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AU - Misra, Santosh K.

AU - Ghoshal, Goutam

AU - Jensen, Tor W.

AU - Ray, Partha S.

AU - Burdette, Everette C.

AU - Pan, Dipanjan

PY - 2015

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AB - Herein we report a bi-modal cancer treatment technique using therapeutic ultrasound in the presence of a novel sorafenib loaded nanobubble for hepatocellular carcinoma. Therapeutic ultrasound was used for improving fusion-triggered drug release from nanobubbles leading to enhanced cytotoxicity in HepG2 cells by greater than two folds improvement in IC50 values. This strategy could also be made compatible with catheter-based devices to derive a highly localized treatment approach, a concept that might be extendable to metastatic cancers as well.

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IS - 78

ER -

Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

Abstract

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