Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko; Marc Kaufman

doi:10.1016/S0006-8993(02)02418-6

Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko
, Marc Kaufman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In decerebrate cats, we found that iontophoretic application of bicuculline, a GABA_A receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

Original language	English (US)
Pages (from-to)	109-113
Number of pages	5
Journal	Brain research
Volume	935
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)02418-6
State	Published - May 10 2002

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(02)02418-6

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title = "Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input",

abstract = "In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.",

author = "Degtyarenko, \{Alexandr M.\} and Marc Kaufman",

note = "Funding Information: This work was supported by a UCDHS research award and by a grant from the NIH (HL 30710). We thank Ms. Angela DiStefano for her technical assistance and typing the manuscript. ",

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T1 - Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

AU - Degtyarenko, Alexandr M.

AU - Kaufman, Marc

N1 - Funding Information: This work was supported by a UCDHS research award and by a grant from the NIH (HL 30710). We thank Ms. Angela DiStefano for her technical assistance and typing the manuscript.

PY - 2002/5/10

Y1 - 2002/5/10

N2 - In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

AB - In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

UR - https://www.scopus.com/pages/publications/0037052628

UR - https://www.scopus.com/pages/publications/0037052628#tab=citedBy

U2 - 10.1016/S0006-8993(02)02418-6

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M3 - Article

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JO - Brain research

JF - Brain research

IS - 1-2

ER -

Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Abstract

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