TY - JOUR
T1 - Bifunctional transfer-messenger RNA
AU - Keiler, Kenneth C.
AU - Ramadoss, Nitya S.
N1 - Funding Information:
We thank Chris Hayes for communicating results before publication. Work by the authors is supported by NIH grant GM68720 .
PY - 2011/11
Y1 - 2011/11
N2 - Transfer-messenger RNA (tmRNA) is a bifunctional RNA that has properties of a tRNA and an mRNA. tmRNA uses these two functions to release ribosomes stalled during translation and target the nascent polypeptides for degradation. This concerted reaction, known as trans-translation, contributes to translational quality control and regulation of gene expression in bacteria. tmRNA is conserved throughout bacteria, and is one of the most abundant RNAs in the cell, suggesting that trans-translation is of fundamental importance for bacterial fitness. Mutants lacking tmRNA activity typically have severe phenotypes, including defects in viability, virulence, and responses to environmental stresses.
AB - Transfer-messenger RNA (tmRNA) is a bifunctional RNA that has properties of a tRNA and an mRNA. tmRNA uses these two functions to release ribosomes stalled during translation and target the nascent polypeptides for degradation. This concerted reaction, known as trans-translation, contributes to translational quality control and regulation of gene expression in bacteria. tmRNA is conserved throughout bacteria, and is one of the most abundant RNAs in the cell, suggesting that trans-translation is of fundamental importance for bacterial fitness. Mutants lacking tmRNA activity typically have severe phenotypes, including defects in viability, virulence, and responses to environmental stresses.
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U2 - 10.1016/j.biochi.2011.05.029
DO - 10.1016/j.biochi.2011.05.029
M3 - Review article
C2 - 21664408
AN - SCOPUS:80053560572
SN - 0300-9084
VL - 93
SP - 1993
EP - 1997
JO - Biochimie
JF - Biochimie
IS - 11
ER -