Big molecule ejection - SIMS vs. MALDI

B. J. Garrison; A. Delcorte; L. V. Zhigilei; T. E. Itina; K. D. Krantzman; Y. G. Yingling; C. M. McQuaw; E. J. Smiley; N. Winograd

doi:10.1016/S0169-4332(02)00661-X

Big molecule ejection - SIMS vs. MALDI

B. J. Garrison, A. Delcorte, L. V. Zhigilei, T. E. Itina, K. D. Krantzman, Y. G. Yingling, C. M. McQuaw, E. J. Smiley, N. Winograd

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Using the results of molecular dynamics (MD) simulations, we discuss the question of whether the observed difference in mass limits in secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) are inherently related to the underlying physics of ejection or rather insufficient experimentation. The simulations show clearly that the physics of large molecule emission in SIMS and MALDI is very different. Consequently, we conclude that larger molecules can be ejected in MALDI than in SIMS.

Original language	English (US)
Pages (from-to)	69-71
Number of pages	3
Journal	Applied Surface Science
Volume	203-204
DOIs	https://doi.org/10.1016/S0169-4332(02)00661-X
State	Published - Jan 15 2003

All Science Journal Classification (ASJC) codes

Condensed Matter Physics
Surfaces and Interfaces
Surfaces, Coatings and Films

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10.1016/S0169-4332(02)00661-X

Cite this

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title = "Big molecule ejection - SIMS vs. MALDI",

abstract = "Using the results of molecular dynamics (MD) simulations, we discuss the question of whether the observed difference in mass limits in secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) are inherently related to the underlying physics of ejection or rather insufficient experimentation. The simulations show clearly that the physics of large molecule emission in SIMS and MALDI is very different. Consequently, we conclude that larger molecules can be ejected in MALDI than in SIMS.",

author = "Garrison, {B. J.} and A. Delcorte and Zhigilei, {L. V.} and Itina, {T. E.} and Krantzman, {K. D.} and Yingling, {Y. G.} and McQuaw, {C. M.} and Smiley, {E. J.} and N. Winograd",

note = "Funding Information: We gratefully acknowledge financial support from the Medical Free Electron Program (Air Force Office of Scientific Research) and the Chemistry Division of the National Science Foundation. The computational support for this work was provided by the IBM Selected University Research Program and the Center for Academic Computing at Penn State University. More results including papers, graphics and animations can be found on the group web page http://galilei.chem.psu.edu/ . Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2003",

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day = "15",

doi = "10.1016/S0169-4332(02)00661-X",

language = "English (US)",

volume = "203-204",

pages = "69--71",

journal = "Applied Surface Science",

issn = "0169-4332",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Big molecule ejection - SIMS vs. MALDI

AU - Garrison, B. J.

AU - Delcorte, A.

AU - Zhigilei, L. V.

AU - Itina, T. E.

AU - Krantzman, K. D.

AU - Yingling, Y. G.

AU - McQuaw, C. M.

AU - Smiley, E. J.

AU - Winograd, N.

N1 - Funding Information: We gratefully acknowledge financial support from the Medical Free Electron Program (Air Force Office of Scientific Research) and the Chemistry Division of the National Science Foundation. The computational support for this work was provided by the IBM Selected University Research Program and the Center for Academic Computing at Penn State University. More results including papers, graphics and animations can be found on the group web page http://galilei.chem.psu.edu/ . Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2003/1/15

Y1 - 2003/1/15

N2 - Using the results of molecular dynamics (MD) simulations, we discuss the question of whether the observed difference in mass limits in secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) are inherently related to the underlying physics of ejection or rather insufficient experimentation. The simulations show clearly that the physics of large molecule emission in SIMS and MALDI is very different. Consequently, we conclude that larger molecules can be ejected in MALDI than in SIMS.

AB - Using the results of molecular dynamics (MD) simulations, we discuss the question of whether the observed difference in mass limits in secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) are inherently related to the underlying physics of ejection or rather insufficient experimentation. The simulations show clearly that the physics of large molecule emission in SIMS and MALDI is very different. Consequently, we conclude that larger molecules can be ejected in MALDI than in SIMS.

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DO - 10.1016/S0169-4332(02)00661-X

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SN - 0169-4332

VL - 203-204

SP - 69

EP - 71

JO - Applied Surface Science

JF - Applied Surface Science

ER -

Big molecule ejection - SIMS vs. MALDI

Abstract

All Science Journal Classification (ASJC) codes

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