Abstract
The receptor binding characteristics of human lymphoblastoid alpha- interferon (IFN) to human Daudi cell line was compared with its binding to membrane homogenates derived from various regions of rat brain. Rat brain membranes bound specifically a detectable amount of I-125 alpha interferon revealing the receptor affinity constant (Kd) of 3.9 - 4.2 x 10-10 M and the Bmax was 0.9 - 1.7 fmoles/mg wet weight tissue depending on the analyzed brain region (the highest Bmax was obtained in the membranes from the hypothalamus region, the lowest one from the spinal cord membranes).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 75 |
| Issue number | 1 |
| State | Published - 1992 |
All Science Journal Classification (ASJC) codes
- General Pharmacology, Toxicology and Pharmaceutics
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology