Bio-Instructive Scaffolds for Musculoskeletal Interfaces

Brittany L. Banik, D. T. Bowers, P. Fattahi, Justin L. Brown

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Tissue interfaces are integral to the function of many tissues and for the synchronous interaction amongst tissues to create a functional whole organism. From a tissue engineering perspective, the interface presents a unique challenge compared to designing a scaffold to replace or repair bulk tissue. It is at the interface that one tissue ends and another begins and where the forces and biochemistry must be correctly transferred so that the connected tissues coordinate to function as a whole. Tissue interfaces are critical to ultimately fulfill the mechanical, physical, and biochemical responses necessary within the body. This chapter will cover the following musculoskeletal interfaces: muscle:tendon (myotendinous), motor neuron:muscle fiber (neuromuscular junctions), cartilage:bone (osteochondral), bone:tendon (osteotendinous), and bone:ligament (osteoligamentous). Key parameters for these musculoskeletal interfaces, such as relevant design rationales, the structure-function relationships, and the formation and maintenance of multitissue systems, will be reviewed and discussed.

Original languageEnglish (US)
Title of host publicationBio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine
PublisherElsevier Inc.
Number of pages31
ISBN (Electronic)9780128033999
ISBN (Print)9780128033944
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Materials Science


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