Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

Tzung K. Hsiai; Sung K. Cho; Pak K. Wong; Michael Ing; Mohammad Navab; Srinuvasa Reddy; Linda L. Demer; Chih M. Ho

Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

Tzung K. Hsiai, Sung K. Cho, Pak K. Wong, Michael Ing, Mohammad Navab, Srinuvasa Reddy, Linda L. Demer, Chih M. Ho

Research output: Contribution to journal › Conference article › peer-review

Abstract

Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 × 80 μm), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).

Original language	English (US)
Pages (from-to)	1828-1829
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	3
State	Published - 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

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title = "Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics",

abstract = "Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 × 80 μm), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).",

author = "Hsiai, {Tzung K.} and Cho, {Sung K.} and Wong, {Pak K.} and Michael Ing and Mohammad Navab and Srinuvasa Reddy and Demer, {Linda L.} and Ho, {Chih M.}",

year = "2002",

language = "English (US)",

volume = "3",

pages = "1828--1829",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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TY - JOUR

T1 - Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

AU - Hsiai, Tzung K.

AU - Cho, Sung K.

AU - Wong, Pak K.

AU - Ing, Michael

AU - Navab, Mohammad

AU - Reddy, Srinuvasa

AU - Demer, Linda L.

AU - Ho, Chih M.

PY - 2002

Y1 - 2002

N2 - Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 × 80 μm), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).

AB - Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 × 80 μm), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).

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UR - http://www.scopus.com/inward/citedby.url?scp=0036911652&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0036911652

SN - 0589-1019

VL - 3

SP - 1828

EP - 1829

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

Y2 - 23 October 2002 through 26 October 2002

ER -

Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

Abstract

All Science Journal Classification (ASJC) codes

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