TY - JOUR
T1 - Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males
T2 - Implications for testosterone replacement therapy
AU - Perry, P. J.
AU - Lund, B. C.
AU - Arndt, S.
AU - Holman, T.
AU - Bever-Stille, K. A.
AU - Paulsen, J.
AU - Demers, L. M.
N1 - Funding Information:
This study was supported by grant RR00059 from the General Clinical Research Centers Program, NCRR, NIH.
PY - 2001
Y1 - 2001
N2 - Andropause is a syndrome described in aging males, is composed of a constellation of physical, sexual, and emotional symptoms, and is thought to be related to declining concentrations of serum testosterone. Numerous studies of testosterone replacement therapy in elderly hypogonadal males have documented the physical benefits of such treatment, but have failed to assess cognition, psychological functioning, and quality of life. Male outpatients greater or equal to 55 years of age completed cognitive, psychological, sexual, and quality of life assessments. A serum sample was provided for bioavailable testosterone assay. The associations between bioavailable testosterone concentrations and neuropsychological testing were assessed using Spearman rank correlation. Overall, bioavailable testosterone was not an important determinant of cognitive, psychological, or sexual functioning or of quality of life. The implications for future studies involving testosterone replacement therapy are discussed.
AB - Andropause is a syndrome described in aging males, is composed of a constellation of physical, sexual, and emotional symptoms, and is thought to be related to declining concentrations of serum testosterone. Numerous studies of testosterone replacement therapy in elderly hypogonadal males have documented the physical benefits of such treatment, but have failed to assess cognition, psychological functioning, and quality of life. Male outpatients greater or equal to 55 years of age completed cognitive, psychological, sexual, and quality of life assessments. A serum sample was provided for bioavailable testosterone assay. The associations between bioavailable testosterone concentrations and neuropsychological testing were assessed using Spearman rank correlation. Overall, bioavailable testosterone was not an important determinant of cognitive, psychological, or sexual functioning or of quality of life. The implications for future studies involving testosterone replacement therapy are discussed.
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U2 - 10.1023/A:1016663523579
DO - 10.1023/A:1016663523579
M3 - Article
C2 - 11534928
AN - SCOPUS:0034861050
SN - 1040-1237
VL - 13
SP - 75
EP - 80
JO - Annals of Clinical Psychiatry
JF - Annals of Clinical Psychiatry
IS - 2
ER -
