Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen

J. C. Carrero-Sánchez, A. L. Elías, R. Mancilla, G. Arrellín, H. Terrones, J. P. Laclette, M. Terrones

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319 Scopus citations


In this report, we compare the toxicological effects between pure carbon multiwalled nanotubes (MWNTs) and N-doped multiwalled carbon (CN x) nanotubes. Different doses of tubes were administered in various ways to mice: nasal, oral, intratracheal, and intraperitoneal. We have found that when MWNTs were injected into the mice's trachea, the mice could die by dyspnea depending on the MWNTs doses. However, CN, nanotubes never caused the death of any mouse. We always found that CN x nanotubes were far more tolerated by the mice when compared to MWNTs. Extremely high concentrations of CN x nanotubes administrated directly into the mice's trachea only induced granulomatous inflammatory responses. Importantly, all other routes of administration did not induce signs of distress or tissue changes on any treated mouse. We therefore believe that CN x nanotubes are less harmful than MWNTs or SWNTs and might be more advantageous for bioapplications.

Original languageEnglish (US)
Pages (from-to)1609-1616
Number of pages8
JournalNano letters
Issue number8
StatePublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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