Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

Urara Hasegawa; Nobuyuki Morimoto; Kazunari Akiyoshi

Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

Urara Hasegawa, Nobuyuki Morimoto, Kazunari Akiyoshi

Materials Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We previously reported that the nanogel of cholesterol-bearing pullulan (CHP) served as a promising carrier for proteins and hydrophobic drugs. In this study, we developed biodegradable hydrrogel with nanogel cross-linked structure (CHPA-PEOSH gel) for tissue engineering. CHPA-PEOSH gel was prepared by Micheal addition of acryloyl group-modified CHP (CHPA) and mercapto group-modified polyethylene oxide (PEOSH). This hydrogel degraded more rapidly in 10% serum-containing medium than in phosphate buffered saline. CHPA-PEOSH gel is a promising candidate as an artificial extracellular matrix for long-term drug release.

Original language	English (US)
Pages	1974
Number of pages	1
State	Published - 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

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title = "Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix",

abstract = "We previously reported that the nanogel of cholesterol-bearing pullulan (CHP) served as a promising carrier for proteins and hydrophobic drugs. In this study, we developed biodegradable hydrrogel with nanogel cross-linked structure (CHPA-PEOSH gel) for tissue engineering. CHPA-PEOSH gel was prepared by Micheal addition of acryloyl group-modified CHP (CHPA) and mercapto group-modified polyethylene oxide (PEOSH). This hydrogel degraded more rapidly in 10% serum-containing medium than in phosphate buffered saline. CHPA-PEOSH gel is a promising candidate as an artificial extracellular matrix for long-term drug release.",

author = "Urara Hasegawa and Nobuyuki Morimoto and Kazunari Akiyoshi",

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TY - CONF

T1 - Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

AU - Hasegawa, Urara

AU - Morimoto, Nobuyuki

AU - Akiyoshi, Kazunari

PY - 2006

Y1 - 2006

N2 - We previously reported that the nanogel of cholesterol-bearing pullulan (CHP) served as a promising carrier for proteins and hydrophobic drugs. In this study, we developed biodegradable hydrrogel with nanogel cross-linked structure (CHPA-PEOSH gel) for tissue engineering. CHPA-PEOSH gel was prepared by Micheal addition of acryloyl group-modified CHP (CHPA) and mercapto group-modified polyethylene oxide (PEOSH). This hydrogel degraded more rapidly in 10% serum-containing medium than in phosphate buffered saline. CHPA-PEOSH gel is a promising candidate as an artificial extracellular matrix for long-term drug release.

AB - We previously reported that the nanogel of cholesterol-bearing pullulan (CHP) served as a promising carrier for proteins and hydrophobic drugs. In this study, we developed biodegradable hydrrogel with nanogel cross-linked structure (CHPA-PEOSH gel) for tissue engineering. CHPA-PEOSH gel was prepared by Micheal addition of acryloyl group-modified CHP (CHPA) and mercapto group-modified polyethylene oxide (PEOSH). This hydrogel degraded more rapidly in 10% serum-containing medium than in phosphate buffered saline. CHPA-PEOSH gel is a promising candidate as an artificial extracellular matrix for long-term drug release.

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M3 - Paper

AN - SCOPUS:33749863285

SP - 1974

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

Abstract

Conference

All Science Journal Classification (ASJC) codes

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